A new class of artificial ionophores has been rationally designed and synthesized linking to a tetrafunctionalized L-treitol spacer two rigid hydrophobic 3beta-hydroxy-5alpha-23,24-bisnorcholanic units and two flexible hydrophilic oligo(ethylene glycol) chains. Compounds 1a and 1b were incorporated into phospholipid vesicles and shown to facilitate Na+-transport.
C2-symmetrical sterol-polyether conjugates as higly efficient synthetic ionophores / Avallone, E.; Izzo, I.; Vuolo, G.; Costabile, M.; Garrisi, D.; Pasquato, Lucia; Scrimin, P.; Tecilla, Paolo; DE RICCARDIS, F.. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 44:(2003), pp. 6121-6124. [10.1016/s0040-4039(03)01454-0]
C2-symmetrical sterol-polyether conjugates as higly efficient synthetic ionophores
PASQUATO, LUCIA;TECILLA, PAOLO;
2003-01-01
Abstract
A new class of artificial ionophores has been rationally designed and synthesized linking to a tetrafunctionalized L-treitol spacer two rigid hydrophobic 3beta-hydroxy-5alpha-23,24-bisnorcholanic units and two flexible hydrophilic oligo(ethylene glycol) chains. Compounds 1a and 1b were incorporated into phospholipid vesicles and shown to facilitate Na+-transport.Pubblicazioni consigliate
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