C2-symmetrical sterol-polyether conjugates as higly efficient synthetic ionophores

A new class of artificial ionophores has been rationally designed and synthesized linking to a tetrafunctionalized L-treitol spacer two rigid hydrophobic 3beta-hydroxy-5alpha-23,24-bisnorcholanic units and two flexible hydrophilic oligo(ethylene glycol) chains. Compounds 1a and 1b were incorporated into phospholipid vesicles and shown to facilitate Na+-transport.

Titolo: C2-symmetrical sterol-polyether conjugates as higly efficient synthetic ionophores
Autori: 
PASQUATO, LUCIA
TECILLA, PAOLO
mostra contributor esterni 
Data di pubblicazione: 2003
Stato di pubblicazione: Pubblicato
Rivista: 
TETRAHEDRON LETTERS  
Abstract: A new class of artificial ionophores has been rationally designed and synthesized linking to a tetrafunctionalized L-treitol spacer two rigid hydrophobic 3beta-hydroxy-5alpha-23,24-bisnorcholanic units and two flexible hydrophilic oligo(ethylene glycol) chains. Compounds 1a and 1b were incorporated into phospholipid vesicles and shown to facilitate Na+-transport.
Handle: http://hdl.handle.net/11368/1701675
Digital Object Identifier (DOI): http://dx.doi.org/10.1016/s0040-4039(03)01454-0
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