A new class of artificial ionophores has been rationally designed and synthesized linking to a tetrafunctionalized L-treitol spacer two rigid hydrophobic 3beta-hydroxy-5alpha-23,24-bisnorcholanic units and two flexible hydrophilic oligo(ethylene glycol) chains. Compounds 1a and 1b were incorporated into phospholipid vesicles and shown to facilitate Na+-transport.
Titolo: | C2-symmetrical sterol-polyether conjugates as higly efficient synthetic ionophores |
Autori: | |
Data di pubblicazione: | 2003 |
Stato di pubblicazione: | Pubblicato |
Rivista: | |
Abstract: | A new class of artificial ionophores has been rationally designed and synthesized linking to a tetrafunctionalized L-treitol spacer two rigid hydrophobic 3beta-hydroxy-5alpha-23,24-bisnorcholanic units and two flexible hydrophilic oligo(ethylene glycol) chains. Compounds 1a and 1b were incorporated into phospholipid vesicles and shown to facilitate Na+-transport. |
Handle: | http://hdl.handle.net/11368/1701675 |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/s0040-4039(03)01454-0 |
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