Both enantiomers of the heterocyclic GABA analogue homo-b-proline (3-pyrrolidineacetic acid) were synthesized by a chemoenzymatic method involving the use of two enantiocomplementary enzymes in the disymmetric hydrolyses of 3-nitromethylglutaric acid diethyl ester
A convenient chemoenzymatic synthesis of (R)-(-) and (S)-(+)-homo-beta-proline / Felluga, Fulvia; Gombac, Valentina; Pitacco, Giuliana; Valentin, Ennio. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - STAMPA. - 15:(2004), pp. 3323-3327. [10.1016/j.tetasy.2004.08.036]
A convenient chemoenzymatic synthesis of (R)-(-) and (S)-(+)-homo-beta-proline
FELLUGA, FULVIA;GOMBAC, VALENTINA;PITACCO, GIULIANA;VALENTIN, ENNIO
2004-01-01
Abstract
Both enantiomers of the heterocyclic GABA analogue homo-b-proline (3-pyrrolidineacetic acid) were synthesized by a chemoenzymatic method involving the use of two enantiocomplementary enzymes in the disymmetric hydrolyses of 3-nitromethylglutaric acid diethyl esterFile in questo prodotto:
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