Both enantiomers of the pharmacologically active GABA analogues 4-amino-3-phenyl and 4-amino-3-(4-chlorophenyl) butyric acid (Baclofen) with high enantiomeric excesses were synthesized by a chemoenzymatic method involving a-chymotrypsin mediated kinetic resolutions of the corresponding 3-phenyl- and 3-(4-chlorophenyl)-4-nitrobutyric acid methyl ester precursors
Titolo: | A short and convenient chemoenzymatic synthesis of both enantiomers of 3-phenylGABA and 3-(4-chlorophenyl)GABA (Baclofen) |
Autori: | |
Data di pubblicazione: | 2005 |
Rivista: | |
Abstract: | Both enantiomers of the pharmacologically active GABA analogues 4-amino-3-phenyl and 4-amino-3-(4-chlorophenyl) butyric acid (Baclofen) with high enantiomeric excesses were synthesized by a chemoenzymatic method involving a-chymotrypsin mediated kinetic resolutions of the corresponding 3-phenyl- and 3-(4-chlorophenyl)-4-nitrobutyric acid methyl ester precursors |
Handle: | http://hdl.handle.net/11368/1702464 |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.tetasy.2005.02.019 |
Appare nelle tipologie: | 1.1 Articolo in Rivista |
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