Both enantiomers of the pharmacologically active GABA analogues 4-amino-3-phenyl and 4-amino-3-(4-chlorophenyl) butyric acid (Baclofen) with high enantiomeric excesses were synthesized by a chemoenzymatic method involving a-chymotrypsin mediated kinetic resolutions of the corresponding 3-phenyl- and 3-(4-chlorophenyl)-4-nitrobutyric acid methyl ester precursors
A short and convenient chemoenzymatic synthesis of both enantiomers of 3-phenylGABA and 3-(4-chlorophenyl)GABA (Baclofen) / Felluga, Fulvia; Gombac, Valentina; Pitacco, Giuliana; Valentin, Ennio. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - STAMPA. - 16:(2005), pp. 1341-1345. [10.1016/j.tetasy.2005.02.019]
A short and convenient chemoenzymatic synthesis of both enantiomers of 3-phenylGABA and 3-(4-chlorophenyl)GABA (Baclofen)
FELLUGA, FULVIA;GOMBAC, VALENTINA;PITACCO, GIULIANA;VALENTIN, ENNIO
2005-01-01
Abstract
Both enantiomers of the pharmacologically active GABA analogues 4-amino-3-phenyl and 4-amino-3-(4-chlorophenyl) butyric acid (Baclofen) with high enantiomeric excesses were synthesized by a chemoenzymatic method involving a-chymotrypsin mediated kinetic resolutions of the corresponding 3-phenyl- and 3-(4-chlorophenyl)-4-nitrobutyric acid methyl ester precursorsPubblicazioni consigliate
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