The synthesis of a series of α-methylene-γ-butyrolactones (compounds 4a, 4b, 6–12, 16, 17) and α,β-unsaturated-δ-lactones (compounds 19−23, 25, 26) starting from 4,4-dimethyldihydrofuran-2,3-dione (1) has been described. Their chemical structures were assigned by spectroscopic evidence. These new compounds exhibited significantly different antiproliferative properties against cultured human tumor cell lines with their IC50 values ranging from 0.88 to > 20.00 μM.
Synthesis and biological properties of new α-methylene-γ-butyrolactones and α,β-unsaturated δ-lactones / Cateni, Francesca; J., Zilic; Zacchigna, Marina; P., Bonivento; F., Frausin; Scarcia, Vito. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0223-5234. - STAMPA. - 41(2):(2006), pp. 192-200. [10.1016/J.EJMECH.2005.10.009]
Synthesis and biological properties of new α-methylene-γ-butyrolactones and α,β-unsaturated δ-lactones
CATENI, FRANCESCA;ZACCHIGNA, MARINA;SCARCIA, VITO
2006-01-01
Abstract
The synthesis of a series of α-methylene-γ-butyrolactones (compounds 4a, 4b, 6–12, 16, 17) and α,β-unsaturated-δ-lactones (compounds 19−23, 25, 26) starting from 4,4-dimethyldihydrofuran-2,3-dione (1) has been described. Their chemical structures were assigned by spectroscopic evidence. These new compounds exhibited significantly different antiproliferative properties against cultured human tumor cell lines with their IC50 values ranging from 0.88 to > 20.00 μM.Pubblicazioni consigliate
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