A polymorphism (PM) in the microsatellite of the promoter region of matrix metalloproteinase 9 (MMP-9), modulating its expression, could play a role in susceptibility to multiple sclerosis (MS). MMP-9 PM was determined in 95 patients with MS (MS Group) and 95 ageand sex-matched controls (Control Group). Comparison of allelic frequencies showed that a higher number of CA repeats characterized the MS group ( P < 0.0001) and prevalence of carriers of z22 CA repeats was higher in the MS than in the Control Group (OR 3.4, 95% CI: 1.7–6.8, P < 0.0001). An earlier age at disease onset was a characteristic of patients with >22 CA repeats (33F10 vs. 28F10, P= 0.027). No differences were found in the main MRI parameters.
MMP-9 microsatellite polymorphism and multiple sclerosis / Fiotti, Nicola; Zivadinov, R.; Altamura, N.; Nasuelli, D.; Bratina, Alessio; Tommasi, M. A.; Bosco, A.; Locatelli, L.; Grop, A.; Cazzato, G.; Guarnieri, Gianfranco; Giansante, Carlo; Zorzon, Marino. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - STAMPA. - 152:(2004), pp. 147-153. [10.1016/j.jneuroim.2004.03.009]
MMP-9 microsatellite polymorphism and multiple sclerosis.
FIOTTI, NICOLA;BRATINA, ALESSIO;GUARNIERI, GIANFRANCO;GIANSANTE, CARLO;ZORZON, MARINO
2004-01-01
Abstract
A polymorphism (PM) in the microsatellite of the promoter region of matrix metalloproteinase 9 (MMP-9), modulating its expression, could play a role in susceptibility to multiple sclerosis (MS). MMP-9 PM was determined in 95 patients with MS (MS Group) and 95 ageand sex-matched controls (Control Group). Comparison of allelic frequencies showed that a higher number of CA repeats characterized the MS group ( P < 0.0001) and prevalence of carriers of z22 CA repeats was higher in the MS than in the Control Group (OR 3.4, 95% CI: 1.7–6.8, P < 0.0001). An earlier age at disease onset was a characteristic of patients with >22 CA repeats (33F10 vs. 28F10, P= 0.027). No differences were found in the main MRI parameters.Pubblicazioni consigliate
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