ArTS Archivio della ricerca di Trieste
ArTS è il sistema di gestione integrata dei dati della ricerca adottato dall' Università degli Studi di Trieste
EnglishC2 symmetric and non-symmetric pseudopeptide inhibitors of HIV-1 protease, containing a S,S,S,S-diaminodiol isostere have been obtained by a synthetic strategy designed to couple a high degree of stereochemical control with complete flexibility in the choice of residues in the central core and flanking chains. Using this approach, inhibitors with IC50 values in the low nanomolar range were assembled from readily available aminoacids and carboxylic acids, chosen with the aid of molecular modelling.
Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/11368/1708349| Titolo: | Flexible synthesis of symmetric and non-symmetric hiv-1 protease inhibitors based on all-s-diaminodiol isosteres |
| Autori interni: | TOSSI, ALESSANDRO BENEDETTI, FABIO MIERTUS, STANISLAV NORBEDO, STEFANO ANTCHEVA, Nikolinka ROMEO, DOMENICO |
| Data di pubblicazione: | 1999 |
| Rivista: | PROTEIN AND PEPTIDE LETTERS |
| Abstract: | C2 symmetric and non-symmetric pseudopeptide inhibitors of HIV-1 protease, containing a S,S,S,S-diaminodiol isostere have been obtained by a synthetic strategy designed to couple a high degree of stereochemical control with complete flexibility in the choice of residues in the central core and flanking chains. Using this approach, inhibitors with IC50 values in the low nanomolar range were assembled from readily available aminoacids and carboxylic acids, chosen with the aid of molecular modelling. |
| Handle: | http://hdl.handle.net/11368/1708349 |
| Appare nelle tipologie: | 1.1 Articolo in Rivista |
File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.