Preparation of the Maleic Anhydride Nucleus from Dichloro gamma-Lactams:Focus on the Role of the N-Substituent in the Functional Rearrangement and in the Hydrolytic Steps

The preparation of 3,4-dialkylsubstituted maleic anhydride nucleus, through the functional rearrangement of dichloro gamma-lactams, allowed the comparison of various N-substituents in the functional rearrangement step. The 2-pyridil group proved to be the most appropriate N-substituent for the hydrolysis of the 5-methoxy-1,5-dihydro-2H-pyrrol-2-one intermediate into the 5-hydroxy adduct and for the hydrolysis of the maleimide nucleus into the maleic anhydride.The oxydation of the 5-hydroxy-1,5-dihydro-2H-pyrrol-2-one into the corresponding maleimide was achieved with mnganese (IV) oxide