Discovery by co-crystallization: High-resolution electron-density maps of HIV-1 aspartyl protease complexed with a potent Phe–Pro isostere-based inhibitor (shown) allowed the determination of the stereochemistry of the inhibitor and an initial assessment of the inhibition properties of this compound without its purification from the epimeric mixture.

A potent HIV protease inhibitor identified in an epimeric mixture by high-resolution protein crystallography

GEREMIA, SILVANO;BENEDETTI, FABIO;BERTI, FEDERICO;RANDACCIO, LUCIO
2006

Abstract

Discovery by co-crystallization: High-resolution electron-density maps of HIV-1 aspartyl protease complexed with a potent Phe–Pro isostere-based inhibitor (shown) allowed the determination of the stereochemistry of the inhibitor and an initial assessment of the inhibition properties of this compound without its purification from the epimeric mixture.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11368/1855508
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