A potent HIV protease inhibitor identified in an epimeric mixture by high-resolution protein crystallography

Geremia, Silvano; Demitri, N; Wuerges, J; Benedetti, Fabio; Berti, Federico; Tell, G; Randaccio, Lucio

doi:10.1002/CMDC.200500063

Discovery by co-crystallization: High-resolution electron-density maps of HIV-1 aspartyl protease complexed with a potent Phe–Pro isostere-based inhibitor (shown) allowed the determination of the stereochemistry of the inhibitor and an initial assessment of the inhibition properties of this compound without its purification from the epimeric mixture.

Titolo:	A potent HIV protease inhibitor identified in an epimeric mixture by high-resolution protein crystallography
Autori:	GEREMIA, SILVANO DEMITRI N WUERGES J BENEDETTI, FABIO BERTI, FEDERICO TELL G RANDACCIO, LUCIO mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2006
Rivista:	CHEMMEDCHEM
Abstract:	Discovery by co-crystallization: High-resolution electron-density maps of HIV-1 aspartyl protease complexed with a potent Phe–Pro isostere-based inhibitor (shown) allowed the determination of the stereochemistry of the inhibitor and an initial assessment of the inhibition properties of this compound without its purification from the epimeric mixture.
Handle:	http://hdl.handle.net/11368/1855508
Digital Object Identifier (DOI):	http://dx.doi.org/10.1002/CMDC.200500063
Appare nelle tipologie:	1.1 Articolo in Rivista

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