Discovery by co-crystallization: High-resolution electron-density maps of HIV-1 aspartyl protease complexed with a potent Phe–Pro isostere-based inhibitor (shown) allowed the determination of the stereochemistry of the inhibitor and an initial assessment of the inhibition properties of this compound without its purification from the epimeric mixture.
Titolo: | A potent HIV protease inhibitor identified in an epimeric mixture by high-resolution protein crystallography |
Autori: | |
Data di pubblicazione: | 2006 |
Rivista: | |
Abstract: | Discovery by co-crystallization: High-resolution electron-density maps of HIV-1 aspartyl protease complexed with a potent Phe–Pro isostere-based inhibitor (shown) allowed the determination of the stereochemistry of the inhibitor and an initial assessment of the inhibition properties of this compound without its purification from the epimeric mixture. |
Handle: | http://hdl.handle.net/11368/1855508 |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/CMDC.200500063 |
Appare nelle tipologie: | 1.1 Articolo in Rivista |
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