A branched high-molecular weight multimeric PEG (MultiPEG), synthesized with a simple assembling procedure that devised the introduction of functional groups with divergent and selective reactivity, was employed as a drug carrier. The permeation process across the intestinal membrane of the same macromolecular conjugate was investigated, mathematically discussed and interpreted according to “Fick’s law”.

New multidrug (dexamethasone and theophylline) PEG-conjugate: Synthesis, in vitro release studies and intestinal permeability

ZACCHIGNA, MARINA;CATENI, FRANCESCA;VOINOVICH, DARIO;GRASSI, Mario;DRIOLI, Sara;BONORA, GIAN MARIA
2009-01-01

Abstract

A branched high-molecular weight multimeric PEG (MultiPEG), synthesized with a simple assembling procedure that devised the introduction of functional groups with divergent and selective reactivity, was employed as a drug carrier. The permeation process across the intestinal membrane of the same macromolecular conjugate was investigated, mathematically discussed and interpreted according to “Fick’s law”.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/2262138
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