A branched high-molecular weight multimeric PEG (MultiPEG), synthesized with a simple assembling procedure that devised the introduction of functional groups with divergent and selective reactivity, was employed as a drug carrier. The permeation process across the intestinal membrane of the same macromolecular conjugate was investigated, mathematically discussed and interpreted according to “Fick’s law”.
New multidrug (dexamethasone and theophylline) PEG-conjugate: Synthesis, in vitro release studies and intestinal permeability / Zacchigna, Marina; Cateni, Francesca; Voinovich, Dario; Grassi, Mario; Drioli, Sara; Bonora, GIAN MARIA. - In: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY. - ISSN 1773-2247. - STAMPA. - 19 (3):(2009), pp. 177-184.
New multidrug (dexamethasone and theophylline) PEG-conjugate: Synthesis, in vitro release studies and intestinal permeability
ZACCHIGNA, MARINA;CATENI, FRANCESCA;VOINOVICH, DARIO;GRASSI, Mario;DRIOLI, Sara;BONORA, GIAN MARIA
2009-01-01
Abstract
A branched high-molecular weight multimeric PEG (MultiPEG), synthesized with a simple assembling procedure that devised the introduction of functional groups with divergent and selective reactivity, was employed as a drug carrier. The permeation process across the intestinal membrane of the same macromolecular conjugate was investigated, mathematically discussed and interpreted according to “Fick’s law”.Pubblicazioni consigliate
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