A research is presented on quantitative structure–activity relationship (QSAR) studies on the more recent class of non-peptidic CCK1 receptor antagonists. Our results suggest that the balance of hydrophobicity and volume dependent polarizability term plays a key role in the antagonism of CCK1 receptor.
2D-QSAR and 3D-QSAR/CoMFA analyses of the N-terminal substituted anthranilic acid based CCK1 receptor antagonists: ‘Hic Rhodus, hic saltus’ / DIMITRA HADJIPAVLOU, Litina; Paolo, Braiuca; Lassiani, Lucia; MICHELA V., Pavan; Varnavas, Antonios. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - STAMPA. - 17:(2009), pp. 5198-5206. [10.1016/j.bmc.2009.05.067]
2D-QSAR and 3D-QSAR/CoMFA analyses of the N-terminal substituted anthranilic acid based CCK1 receptor antagonists: ‘Hic Rhodus, hic saltus’
LASSIANI, LUCIA;VARNAVAS, ANTONIOS
2009-01-01
Abstract
A research is presented on quantitative structure–activity relationship (QSAR) studies on the more recent class of non-peptidic CCK1 receptor antagonists. Our results suggest that the balance of hydrophobicity and volume dependent polarizability term plays a key role in the antagonism of CCK1 receptor.Pubblicazioni consigliate
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