A research is presented on quantitative structure–activity relationship (QSAR) studies on the more recent class of non-peptidic CCK1 receptor antagonists. Our results suggest that the balance of hydrophobicity and volume dependent polarizability term plays a key role in the antagonism of CCK1 receptor.
2D-QSAR and 3D-QSAR/CoMFA analyses of the N-terminal substituted anthranilic acid based CCK1 receptor antagonists: ‘Hic Rhodus, hic saltus’
LASSIANI, LUCIA;VARNAVAS, ANTONIOS
2009-01-01
Abstract
A research is presented on quantitative structure–activity relationship (QSAR) studies on the more recent class of non-peptidic CCK1 receptor antagonists. Our results suggest that the balance of hydrophobicity and volume dependent polarizability term plays a key role in the antagonism of CCK1 receptor.File in questo prodotto:
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