Two probes consisting of vitamin B12 (CNCbl) conjugated to Gd chelates by esterification of the ribose 5’-OH moiety, Gd–DTPA–CNCbl (1; DTPA=diethylenetriamine- N,N,N’,N’’,N’’-pentaacetic acid) and Gd–TTHA–CNCbl (2; TTHA=tri- ACHTUNGTRENUNGethylenetetramine-N,N,N’,N’’,N’’’,N’’’- hexaacetic acid), have been synthesised and characterised.
Release of toxic Gd3+ ions to tumour cells by vitamin B12 bioconjugates
SIEGA, PATRIZIA;DREOS, RENATA;GEREMIA, SILVANO;RANDACCIO, LUCIO
2009-01-01
Abstract
Two probes consisting of vitamin B12 (CNCbl) conjugated to Gd chelates by esterification of the ribose 5’-OH moiety, Gd–DTPA–CNCbl (1; DTPA=diethylenetriamine- N,N,N’,N’’,N’’-pentaacetic acid) and Gd–TTHA–CNCbl (2; TTHA=tri- ACHTUNGTRENUNGethylenetetramine-N,N,N’,N’’,N’’’,N’’’- hexaacetic acid), have been synthesised and characterised.File in questo prodotto:
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