The acute oral toxicity of palytoxin (PLTX), a highly toxic compound associated with seafood intoxication in tropical and subtropical areas, was investigated in mice. After gavage administration (300-1697 µg/kg) to groups of 5 female CD-1 mice, signs of toxicity and lethality were recorded for 24 h. The LD50 was 767 µg/kg (95% confidence limits: 549-1039 µg/kg) and the main symptoms observed were scratching, jumping, respiratory distress and paralysis. Hematoclinical analyses showed increased levels of creatine phosphokinase and lactate dehydrogenase at doses of 600 µg/kg and above, and aspartate transaminase at 848 µg/kg and above. Histological analysis revealed acute inflammation of the forestomach in mice surviving up to 24h after administration (424-1200 µg/kg). Other histological alterations were observed in the liver and pancreas, while cardiac and skeletal muscle cells revealed only ultrastructural alterations visible by transmission electron microscopy.

Palytoxin toxicity after acute oral administration in mice

SOSA, SILVIO;DEL FAVERO, GIORGIA;DE BORTOLI, MARCO;VITA, FRANCESCA;SORANZO, MARIA ROSA;BELTRAMO, DARIO;TUBARO, AURELIA
2009-01-01

Abstract

The acute oral toxicity of palytoxin (PLTX), a highly toxic compound associated with seafood intoxication in tropical and subtropical areas, was investigated in mice. After gavage administration (300-1697 µg/kg) to groups of 5 female CD-1 mice, signs of toxicity and lethality were recorded for 24 h. The LD50 was 767 µg/kg (95% confidence limits: 549-1039 µg/kg) and the main symptoms observed were scratching, jumping, respiratory distress and paralysis. Hematoclinical analyses showed increased levels of creatine phosphokinase and lactate dehydrogenase at doses of 600 µg/kg and above, and aspartate transaminase at 848 µg/kg and above. Histological analysis revealed acute inflammation of the forestomach in mice surviving up to 24h after administration (424-1200 µg/kg). Other histological alterations were observed in the liver and pancreas, while cardiac and skeletal muscle cells revealed only ultrastructural alterations visible by transmission electron microscopy.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/2290916
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