Stereostructure and biological activity of 42-hydroxy-palytoxin: a new palytoxin analogue from Hawaiian Palythoa subspecies

Ciminiello, P.; Dell'Aversano, C.; Dello Iacovo, E.; Fattorusso, E.; Forino, M.; Grauso, L.; Tartaglione, L.; Florio, Chiara; Lorenzon, Paola; De Bortoli, M.; Tubaro, Aurelia; Poli, M.; Bignami, G.

doi:10.1021/tx900259v

This paper reports on the analysis of the toxin content from Palythoa tuberculosa and Palythoa toxica samples collected off of the Hawaiian coast. Our work, based on in-depth high-resolution liquid chromatography-mass spectrometry analysis along with extensive NMR study, led us to structurally characterize 42-hydroxy-palytoxin, a new palytoxin congener. This toxin and palytoxin itself appeared to be the major components of toxic extract from a P. tuberculosa sample, while 42-hydroxy-palytoxin was proven by far to be the main palytoxin derivative in P. toxica. Functional studies on this new palytoxin-like compound suggest that the new palytoxin analogue and palytoxin itself present similar biological activities.

Titolo:	Stereostructure and biological activity of 42-hydroxy-palytoxin: a new palytoxin analogue from Hawaiian Palythoa subspecies
Autori:	P. Ciminiello C. Dell'Aversano E. Dello Iacovo E. Fattorusso M. Forino L. Grauso L. Tartaglione FLORIO, CHIARA LORENZON, Paola M. De Bortoli TUBARO, AURELIA M. Poli G. Bignami mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2009
Rivista:	CHEMICAL RESEARCH IN TOXICOLOGY
Abstract:	This paper reports on the analysis of the toxin content from Palythoa tuberculosa and Palythoa toxica samples collected off of the Hawaiian coast. Our work, based on in-depth high-resolution liquid chromatography-mass spectrometry analysis along with extensive NMR study, led us to structurally characterize 42-hydroxy-palytoxin, a new palytoxin congener. This toxin and palytoxin itself appeared to be the major components of toxic extract from a P. tuberculosa sample, while 42-hydroxy-palytoxin was proven by far to be the main palytoxin derivative in P. toxica. Functional studies on this new palytoxin-like compound suggest that the new palytoxin analogue and palytoxin itself present similar biological activities.
Handle:	http://hdl.handle.net/11368/2290980
Digital Object Identifier (DOI):	http://dx.doi.org/10.1021/tx900259v
Appare nelle tipologie:	1.1 Articolo in Rivista

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