Chiral non-racemic 1,4-dihydropyridazines were prepared by the reaction of 1,2-diaza-1,3-dienes with arylacetaldehydes under organocatalytic conditions. L-Proline and (S)-(+)-1-(2-pyrrolidinylmethyl)pyrrolidine coupled with trifluoroacetic acid were used as organocatalysts. Enantiomeric excesses ranged from 25% to 78%.
Organocatalyzed synthesis of chiral non-racemic 1,4-dihydropyridazines / Pitacco, G., O. A., A., L., D.C., G., F., Felluga, F., Forzato, C., F., M., Nitti, P., Valentin, E., Zangrando, E.. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - STAMPA. - 21/2010:(2010), pp. 617-622. [10.1016/j.tetasy.2010.03.007]
Organocatalyzed synthesis of chiral non-racemic 1,4-dihydropyridazines
PITACCO, GIULIANA;FELLUGA, FULVIA;FORZATO, Cristina;NITTI, PATRIZIA;VALENTIN, ENNIO;ZANGRANDO, ENNIO
2010-01-01
Abstract
Chiral non-racemic 1,4-dihydropyridazines were prepared by the reaction of 1,2-diaza-1,3-dienes with arylacetaldehydes under organocatalytic conditions. L-Proline and (S)-(+)-1-(2-pyrrolidinylmethyl)pyrrolidine coupled with trifluoroacetic acid were used as organocatalysts. Enantiomeric excesses ranged from 25% to 78%.File in questo prodotto:
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