Supercritical fluid extraction is a potential technique for the purification of pharmaceutical products containing residual solvents. The solubilities of the drugs in supercritical carbon dioxide are being measured as part of a program in which the potential applications of this technology are being investigated. The solubilities of three inhibitors of inflammatory activity, Ketoprofen, Piroxicam, and Nimesulide, in supercritical CO2, measured using a dynamic saturation technique, are reported at pressures between 100 bar and 220 bar and at two temperatures: 312.5 K and 331.5 K. These chemicals have relatively high solubilities with values ranging from 4 10-6 to 15 10-4 mole fraction. The solubilities exhibit a clear dependence on the solvent density, and this has been used to provide a simple and precise correlation of the data.
Solubility of Anti-Inflammatory Drugs in Supercritical Carbon Dioxide
KIKIC, IRENEO;ALESSI, PAOLO;CORTESI, ANGELO;
1996-01-01
Abstract
Supercritical fluid extraction is a potential technique for the purification of pharmaceutical products containing residual solvents. The solubilities of the drugs in supercritical carbon dioxide are being measured as part of a program in which the potential applications of this technology are being investigated. The solubilities of three inhibitors of inflammatory activity, Ketoprofen, Piroxicam, and Nimesulide, in supercritical CO2, measured using a dynamic saturation technique, are reported at pressures between 100 bar and 220 bar and at two temperatures: 312.5 K and 331.5 K. These chemicals have relatively high solubilities with values ranging from 4 10-6 to 15 10-4 mole fraction. The solubilities exhibit a clear dependence on the solvent density, and this has been used to provide a simple and precise correlation of the data.Pubblicazioni consigliate
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