This study investigated how 5'-UTR of DEFB1 gene (encoding for the human beta-defensin-1) affects mRNA secondary structure and its correlation with translation efficiency in the susceptibility of diseases. It was possible to determine DEFB1 mRNA folding under the influence of 5'-UTR SNPs haplotypes and putative alternative transcript lengths. Different DEFB1 mRNAs that fold in a pattern that is haplotype and length-dependent are potentially able to drive changes in peptide expression dynamics.
The sound of silence: human beta-defensin-1 gene untranslated SNPs change the predicted mRNA secondary structure in a length-dependent manner / M. S., Naslavsky; Crovella, Sergio; J. L., Lima Filho; C. R. C., Rocha. - In: IMMUNOLOGY LETTERS. - ISSN 0165-2478. - STAMPA. - 129:(2010), pp. 53-55. [10.1016/j.imlet.2009.12.024]
The sound of silence: human beta-defensin-1 gene untranslated SNPs change the predicted mRNA secondary structure in a length-dependent manner.
CROVELLA, SERGIO;
2010-01-01
Abstract
This study investigated how 5'-UTR of DEFB1 gene (encoding for the human beta-defensin-1) affects mRNA secondary structure and its correlation with translation efficiency in the susceptibility of diseases. It was possible to determine DEFB1 mRNA folding under the influence of 5'-UTR SNPs haplotypes and putative alternative transcript lengths. Different DEFB1 mRNAs that fold in a pattern that is haplotype and length-dependent are potentially able to drive changes in peptide expression dynamics.Pubblicazioni consigliate
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