Saulsbury et al emphasize the diagnostic challenge of periodic fevers in pediatrics by describing a case of PFAPA (Periodic Fever, Aphthous stomatitis, Pharyngitis, and Cervical Adenopathy) that was eventually diagnosed as TNFa Receptor-Associated Period Fever (TRAPS). PFAPA is a syndrome and not a specific disease and—as pointed out previously—some symptoms, for instance aphthous stomatitis, may not be present. Moreover, other symptoms are very common, for example abdominal pain, which is present in 60% of all cases. The importance of these symptoms warrants in many children the evaluation of different diagnoses, including other periodic fevers (hyper-IgD syndrome [HIDS], TRAPS) and even Crohn’s disease. We recently described three cases of HIDS in which the disease onset was characterized by a PFAPA-like symptomatology and by severe abdominal complaints.

CARD15/NOD2 mutations are not related to abdominal PFAPA.

A. Tommasini
Conceptualization
2006

Abstract

Saulsbury et al emphasize the diagnostic challenge of periodic fevers in pediatrics by describing a case of PFAPA (Periodic Fever, Aphthous stomatitis, Pharyngitis, and Cervical Adenopathy) that was eventually diagnosed as TNFa Receptor-Associated Period Fever (TRAPS). PFAPA is a syndrome and not a specific disease and—as pointed out previously—some symptoms, for instance aphthous stomatitis, may not be present. Moreover, other symptoms are very common, for example abdominal pain, which is present in 60% of all cases. The importance of these symptoms warrants in many children the evaluation of different diagnoses, including other periodic fevers (hyper-IgD syndrome [HIDS], TRAPS) and even Crohn’s disease. We recently described three cases of HIDS in which the disease onset was characterized by a PFAPA-like symptomatology and by severe abdominal complaints.
Pubblicato
http://dx.doi.org/10.1016/j.jpeds.2006.02.032
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11368/2299057
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 12
  • ???jsp.display-item.citation.isi??? 8
social impact