Long term exposure to gluten in coeliacs, and coeliac disease (CD) diagnosis after 16 years of age2 may induce type 1 diabetes (T1D) and other autoimmune disorders. Increased prevalence of CD among diabetics and their relatives is well documented. Early introduction of gluten to children at high risk for T1D produces T1D associated islet autoantibodies. Similarly, in the absence of overt clinical symptoms of T1D, some coeliac children produce diabetes autoantibodies in a gluten dependent manner. In diabetics, intestinal challenge with gluten produces mucosal recruitment of lymphocytes, similar to that in CD patients. In diabetics, however, there is no production of CD related antitissue transglutaminase antibodies (antitTG). We have used a phage display assay to show that in CD patients, production of antitTG is limited to the intestine.
Cryptic gluten intolerance in type 1 diabetes: identifying suitable candidates for a gluten free diet.
D. Sblattero;A. Tommasini;F. Florian;
2006-01-01
Abstract
Long term exposure to gluten in coeliacs, and coeliac disease (CD) diagnosis after 16 years of age2 may induce type 1 diabetes (T1D) and other autoimmune disorders. Increased prevalence of CD among diabetics and their relatives is well documented. Early introduction of gluten to children at high risk for T1D produces T1D associated islet autoantibodies. Similarly, in the absence of overt clinical symptoms of T1D, some coeliac children produce diabetes autoantibodies in a gluten dependent manner. In diabetics, intestinal challenge with gluten produces mucosal recruitment of lymphocytes, similar to that in CD patients. In diabetics, however, there is no production of CD related antitissue transglutaminase antibodies (antitTG). We have used a phage display assay to show that in CD patients, production of antitTG is limited to the intestine.Pubblicazioni consigliate
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