Some para-substituted 1-aryl-3,3-dimethyltriazenes were oxidized with tert-butyl hydroperoxide in the presence of vanadium pentoxide as a catalyst. Under these conditions, the corresponding 1-aryl-3-formyl-3-methyltriazenes, 1-aryl-3-tert-butylperoxymethyl-3-methyltriazenes, and p-nitrobenzenes were obtained. The 1-aryl-3-formyl-3-methyltriazenes might play a role in the metabolic oxidation of the 1-aryl-3,3-dimethyltriazenes, which are active as mutagenic, carcinogenic, and antitumor agents.
Synthesis of 1-aryl-3-formyl-3-methyltriazenes, potential metabolites of 1-aryl-3,3-dimethyltriazenes / Lassiani, Lucia; C., Nisi; F., Sigon; Sava, Gianni; Giraldi, Tullio. - In: JOURNAL OF PHARMACEUTICAL SCIENCES. - ISSN 0022-3549. - STAMPA. - 69:(1980), pp. 1098-1099.
Synthesis of 1-aryl-3-formyl-3-methyltriazenes, potential metabolites of 1-aryl-3,3-dimethyltriazenes.
LASSIANI, LUCIA;SAVA, GIANNI;GIRALDI, TULLIO
1980-01-01
Abstract
Some para-substituted 1-aryl-3,3-dimethyltriazenes were oxidized with tert-butyl hydroperoxide in the presence of vanadium pentoxide as a catalyst. Under these conditions, the corresponding 1-aryl-3-formyl-3-methyltriazenes, 1-aryl-3-tert-butylperoxymethyl-3-methyltriazenes, and p-nitrobenzenes were obtained. The 1-aryl-3-formyl-3-methyltriazenes might play a role in the metabolic oxidation of the 1-aryl-3,3-dimethyltriazenes, which are active as mutagenic, carcinogenic, and antitumor agents.Pubblicazioni consigliate
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