Boropinic acid is a natural isopentenyloxycinnamic acid extracted from the aerial parts of Boronia pinnata Sm. (Rutaceae) with soybean 5-lipoxygenase inhibitory activity. In this paper the topical anti-inflammatory activity of boropinic acid and some of its natural and semi-synthetic derivatives was evaluated using the Croton oil ear test in mice as a model of acute inflammation. Some of the tested compounds (15, 17, 19, 20) revealed an effect comparable (ID50 = 0.18 0.72 lmol/cm2) to that of the reference drug indomethacin (ID50 = 0.23 lmol/cm2), a non-steroidal anti-inflammatory drug.
Topical anti-inflammatory activity of boropinic acid and its natural and semi-synthetic derivatives / Epifano, F.; Sosa, Silvio; Tubaro, Aurelia; Marcotullio, M. C.; Curini, M.; Genovese, S.. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - STAMPA. - 21:(2011), pp. 769-772. [10.1016/j.bmcl.2010.11.107]
Topical anti-inflammatory activity of boropinic acid and its natural and semi-synthetic derivatives.
SOSA, SILVIO;TUBARO, AURELIA;
2011-01-01
Abstract
Boropinic acid is a natural isopentenyloxycinnamic acid extracted from the aerial parts of Boronia pinnata Sm. (Rutaceae) with soybean 5-lipoxygenase inhibitory activity. In this paper the topical anti-inflammatory activity of boropinic acid and some of its natural and semi-synthetic derivatives was evaluated using the Croton oil ear test in mice as a model of acute inflammation. Some of the tested compounds (15, 17, 19, 20) revealed an effect comparable (ID50 = 0.18 0.72 lmol/cm2) to that of the reference drug indomethacin (ID50 = 0.23 lmol/cm2), a non-steroidal anti-inflammatory drug.Pubblicazioni consigliate
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