Chemical reduction of diethyl 1-oxo-hexylsuccinate resulted in the formation of the corresponding cis and trans disubstituted y-butyrolactones. Both racemic diastereomers were resolved by means of lipolytic enzymes leading to the precursors of interesting natural products such as (-)-methylenolactocin and (-)phaseolinic acid
Asymmetric Resolution of Diasteroisomeric 4-Ethoxycarbonyl-5-pentyl-gamma-butyrolactones by Crude PLE-mediated Hydrolysis / Drioli, Sara; Felluga, Fulvia; Forzato, Cristina; Nitti, Patrizia; Pitacco, Giuliana; Valentin, Ennio. - In: JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC. - ISSN 1381-1177. - STAMPA. - (1997), pp. 203-207. [10.1016/S1381-1177(96)00046-X]
Asymmetric Resolution of Diasteroisomeric 4-Ethoxycarbonyl-5-pentyl-gamma-butyrolactones by Crude PLE-mediated Hydrolysis
DRIOLI, Sara;FELLUGA, FULVIA;FORZATO, Cristina;NITTI, PATRIZIA;PITACCO, GIULIANA;VALENTIN, ENNIO
1997-01-01
Abstract
Chemical reduction of diethyl 1-oxo-hexylsuccinate resulted in the formation of the corresponding cis and trans disubstituted y-butyrolactones. Both racemic diastereomers were resolved by means of lipolytic enzymes leading to the precursors of interesting natural products such as (-)-methylenolactocin and (-)phaseolinic acidPubblicazioni consigliate
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