Asymmetric Resolution of Diasteroisomeric 4-Ethoxycarbonyl-5-pentyl-gamma-butyrolactones by Crude PLE-mediated Hydrolysis

Chemical reduction of diethyl 1-oxo-hexylsuccinate resulted in the formation of the corresponding cis and trans disubstituted y-butyrolactones. Both racemic diastereomers were resolved by means of lipolytic enzymes leading to the precursors of interesting natural products such as (-)-methylenolactocin and (-)phaseolinic acid



Titolo: Asymmetric Resolution of Diasteroisomeric 4-Ethoxycarbonyl-5-pentyl-gamma-butyrolactones by Crude PLE-mediated Hydrolysis
Autori: 
DRIOLI, Sara
FELLUGA, FULVIA
FORZATO, Cristina
NITTI, PATRIZIA
PITACCO, GIULIANA
VALENTIN, ENNIO
Data di pubblicazione: 1997
Rivista: 
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC  
Abstract: Chemical reduction of diethyl 1-oxo-hexylsuccinate resulted in the formation of the corresponding cis and trans disubstituted y-butyrolactones. Both racemic diastereomers were resolved by means of lipolytic enzymes leading to the precursors of interesting natural products such as (-)-methylenolactocin and (-)phaseolinic acid
Handle: http://hdl.handle.net/11368/2309403
Digital Object Identifier (DOI): http://dx.doi.org/10.1016/S1381-1177(96)00046-X
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