Freezing of gait is a warning sign of Parkinson’s disease. One could distinguish off-freezing, which is associated with dopaminergic therapy and to its titration, and it is clinically related to wearing-off phenomenon. Differently, the on-freezing phenomenon seems to be related to a neural disruption of the frontal-parietal-basal ganglia-pontine projections; clinically, it does not respond to therapy modifications or to different drug titration. In a group of patients with on-freezing, we have detected an alteration of focusing attention, an impairment of set-shifting, in addition to poor abstract reasoning and a reduction of planning. These aspects have been even more evident, when compared with the results obtained by a group of PD patients, without freezing.
The On-freezing phenomenon: cognitive and behavioural aspects / Moretti, Rita; Torre, P.; Antonello, Rm; Esposito, F; 2011, Bellini G. Parkinson’s D. i. s. e. a. s. e. Special issue: Non Motor Symptoms of P. D.; In, Press. - In: PARKINSON'S DISEASE. - ISSN 2042-0080. - ELETTRONICO. - 2011:(2011), pp. 56-63. [10.4061/2011/746303]
The On-freezing phenomenon: cognitive and behavioural aspects.
MORETTI, Rita;
2011-01-01
Abstract
Freezing of gait is a warning sign of Parkinson’s disease. One could distinguish off-freezing, which is associated with dopaminergic therapy and to its titration, and it is clinically related to wearing-off phenomenon. Differently, the on-freezing phenomenon seems to be related to a neural disruption of the frontal-parietal-basal ganglia-pontine projections; clinically, it does not respond to therapy modifications or to different drug titration. In a group of patients with on-freezing, we have detected an alteration of focusing attention, an impairment of set-shifting, in addition to poor abstract reasoning and a reduction of planning. These aspects have been even more evident, when compared with the results obtained by a group of PD patients, without freezing.Pubblicazioni consigliate
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