The different protein isoforms generated from the vascular endothelial growth factor-A (VEGF-A) gene, an essential regulator of blood vessel formation, differ in biochemical property and functional activity. Despite the relevance of VEGF-A for both normal and pathologic angiogenesis, our understanding of the molecular mechanisms governing alternative splicing of its pre-mRNA is still in its infancy.

Non-redundant functions of the protein isoforms arising from alternative splicing of the VEGF-A pre-mRNA.

GIACCA, MAURO
2010-01-01

Abstract

The different protein isoforms generated from the vascular endothelial growth factor-A (VEGF-A) gene, an essential regulator of blood vessel formation, differ in biochemical property and functional activity. Despite the relevance of VEGF-A for both normal and pathologic angiogenesis, our understanding of the molecular mechanisms governing alternative splicing of its pre-mRNA is still in its infancy.
2010
http://dx.doi.org/10.4161/trns.1.3.13229
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/2493549
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