The different protein isoforms generated from the vascular endothelial growth factor-A (VEGF-A) gene, an essential regulator of blood vessel formation, differ in biochemical property and functional activity. Despite the relevance of VEGF-A for both normal and pathologic angiogenesis, our understanding of the molecular mechanisms governing alternative splicing of its pre-mRNA is still in its infancy.
Non-redundant functions of the protein isoforms arising from alternative splicing of the VEGF-A pre-mRNA / Giacca, M.. - In: TRANSCRIPTION. - ISSN 2154-1264. - STAMPA. - 1:(2010), pp. 149-153. [10.4161/trns.1.3.13229]
Non-redundant functions of the protein isoforms arising from alternative splicing of the VEGF-A pre-mRNA.
GIACCA, MAURO
2010-01-01
Abstract
The different protein isoforms generated from the vascular endothelial growth factor-A (VEGF-A) gene, an essential regulator of blood vessel formation, differ in biochemical property and functional activity. Despite the relevance of VEGF-A for both normal and pathologic angiogenesis, our understanding of the molecular mechanisms governing alternative splicing of its pre-mRNA is still in its infancy.File in questo prodotto:
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