1-(3,5-Diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives were synthesized and tested for their in vitro antifungal and antimycobacterial activities. These imidazole derivatives showed an excellent antifungal activity against a clinical strain of Candida albicans and an interesting antitubercular activity against Mycobacterium tuberculosis H37Rv reference strain.
Antimycobacterial activity of new 3,5-disubstituted 1,3,4-oxadiazol-2(3H)-one derivatives. Molecular modeling investigations / Zampieri, Daniele; Mamolo, MARIA GRAZIA; Laurini, Erik; Fermeglia, Maurizio; Posocco, Paola; Pricl, Sabrina; Banfi, Elena; Scialino, Giuditta; Vio, Luciano. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - STAMPA. - 17:(2009), pp. 4693-4707. [10.1016/j.bmc.2009.04.055]
Antimycobacterial activity of new 3,5-disubstituted 1,3,4-oxadiazol-2(3H)-one derivatives. Molecular modeling investigations
ZAMPIERI, DANIELE;MAMOLO, MARIA GRAZIA;LAURINI, ERIK;FERMEGLIA, MAURIZIO;POSOCCO, PAOLA;PRICL, SABRINA;BANFI, ELENA;SCIALINO, Giuditta;VIO, LUCIANO
2009-01-01
Abstract
1-(3,5-Diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives were synthesized and tested for their in vitro antifungal and antimycobacterial activities. These imidazole derivatives showed an excellent antifungal activity against a clinical strain of Candida albicans and an interesting antitubercular activity against Mycobacterium tuberculosis H37Rv reference strain.Pubblicazioni consigliate
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