1-(3,5-Diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives were synthesized and tested for their in vitro antifungal and antimycobacterial activities. These imidazole derivatives showed an excellent antifungal activity against a clinical strain of Candida albicans and an interesting antitubercular activity against Mycobacterium tuberculosis H37Rv reference strain.
Antimycobacterial activity of new 3,5-disubstituted 1,3,4-oxadiazol-2(3H)-one derivatives. Molecular modeling investigations
ZAMPIERI, DANIELE;MAMOLO, MARIA GRAZIA;LAURINI, ERIK;FERMEGLIA, MAURIZIO;POSOCCO, PAOLA;PRICL, SABRINA;BANFI, ELENA;SCIALINO, Giuditta;VIO, LUCIANO
2009-01-01
Abstract
1-(3,5-Diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives were synthesized and tested for their in vitro antifungal and antimycobacterial activities. These imidazole derivatives showed an excellent antifungal activity against a clinical strain of Candida albicans and an interesting antitubercular activity against Mycobacterium tuberculosis H37Rv reference strain.File in questo prodotto:
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