The kinetics of the hydrolysis of indomethacin and related compounds were studied in an alkaline medium at 25°. The pseudo-first-order rate constants were evaluated from log absorbance versus time plots in the ultraviolet. These compounds showed a second-order rate constant at low concentrations of hydroxide ion and a first-order rate constant at higher concentrations of hydroxide ion.
Kinetics and mechanism of the basic hydrolysis of indomethacin and related compounds: a reevaluation / A., Cipiciani; Ebert, Cynthia; Linda, Paolo; Rubessa, Fulvio; G., Savelli. - In: JOURNAL OF PHARMACEUTICAL SCIENCES. - ISSN 1520-6017. - STAMPA. - 72:(1983), pp. 1075-1076. [10.1002/jps.2600720928]
Kinetics and mechanism of the basic hydrolysis of indomethacin and related compounds: a reevaluation
EBERT, CYNTHIA;LINDA, PAOLO;RUBESSA, FULVIO;
1983-01-01
Abstract
The kinetics of the hydrolysis of indomethacin and related compounds were studied in an alkaline medium at 25°. The pseudo-first-order rate constants were evaluated from log absorbance versus time plots in the ultraviolet. These compounds showed a second-order rate constant at low concentrations of hydroxide ion and a first-order rate constant at higher concentrations of hydroxide ion.Pubblicazioni consigliate
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