Celiac disease is a multisystemic autoimmune disease of the small bowel induced in genetically subjects by the gluten. High specific and gluten-dependent production of autoantibodies targeting self-proteins of the transglutaminase family are synthesized only at the intestinal mucosa. These anti-transglutamimnase antibodies are found deposited in intestinal and extraintestinal tissue where they might exert an adverse biological effects, together with the intestinal mucosal gliadin-specific T lymphocytes. Here we report a brief review article of anti-transglutaminase antibodies effects discussing their roles in the pathogenesis of several clinical manifestations of the celiac disease.
Gluten-dependent intestinal autoimmune response
NOT, TARCISIO
2012-01-01
Abstract
Celiac disease is a multisystemic autoimmune disease of the small bowel induced in genetically subjects by the gluten. High specific and gluten-dependent production of autoantibodies targeting self-proteins of the transglutaminase family are synthesized only at the intestinal mucosa. These anti-transglutamimnase antibodies are found deposited in intestinal and extraintestinal tissue where they might exert an adverse biological effects, together with the intestinal mucosal gliadin-specific T lymphocytes. Here we report a brief review article of anti-transglutaminase antibodies effects discussing their roles in the pathogenesis of several clinical manifestations of the celiac disease.Pubblicazioni consigliate
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