Lipases, when covalently modified with poly(ethylene glycol), catalyse the acylation of hydrophilic substrates in organic solvents with increase in the reaction rate even in the presence of 4% water. As a further result the modified Lipoprotein lipase from Pseudomonas species acylates only amino group in serine-I~-naphthylamide.
Chemoselectivity and enhanced activity of poly(ethylene glycol)-modified lipases acylating hydrophilic amino acid derivatives in organic solvents
EBERT, CYNTHIA;GARDOSSI, Lucia;LINDA, PAOLO;
1994-01-01
Abstract
Lipases, when covalently modified with poly(ethylene glycol), catalyse the acylation of hydrophilic substrates in organic solvents with increase in the reaction rate even in the presence of 4% water. As a further result the modified Lipoprotein lipase from Pseudomonas species acylates only amino group in serine-I~-naphthylamide.File in questo prodotto:
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