Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.

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doi:10.1038/ng.2352

Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10(-8)). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ∼110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.

Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations / Okada, Y., Sim, X., Go, M.j., Wu, J.y., Gu, D., Takeuchi, F., Takahashi, A., Maeda, S., Tsunoda, T., Chen, P., Lim, S.c., Wong, T.y., Liu, J., Young, T.l., Aung, T., Seielstad, M., Teo, Y.y., Kim, Y.j., Lee, J.y., Han, B.g., et al.. - In: NATURE GENETICS. - ISSN 1061-4036. - 44:(2012), pp. 904-909. [10.1038/ng.2352]