Recently two new slow-release preparations (clonidine “perlongetten” 250 mcg CP, and cloni dine “perlongetten” 150 mcg + chlorthalidone 15 mg, CP + D) gave been presented. The prolonged action of CP and CP + D may permit once daily administration of the drug and thus obtain better patient compliance. The hypotensive effect of CP or CP + D and possible side effects have been esamined during a 3-week trial in 19 hypertensive subjects. It was found that in mild and in some cases of moderate hypertension a single daily dose of CP or CP + D is apt to normalize blood pressure for 24 hrs. In patients with moderate and severe hypertension blood pressure is satisfactorily controlled by b.i.d. administration of CP or CP + D. The hypotensive action of the two preparations did not show consistent differences while tolerance was slightly better for CP + D.

Comparative evaluation of the extended hypotensive effect of slow-released clonidine administered alone or in association with diuretics

BELLINI, GIUSEPPE;COSENZI, ALESSANDRO;CARRETTA, RENZO;FABRIS, BRUNO;
1983

Abstract

Recently two new slow-release preparations (clonidine “perlongetten” 250 mcg CP, and cloni dine “perlongetten” 150 mcg + chlorthalidone 15 mg, CP + D) gave been presented. The prolonged action of CP and CP + D may permit once daily administration of the drug and thus obtain better patient compliance. The hypotensive effect of CP or CP + D and possible side effects have been esamined during a 3-week trial in 19 hypertensive subjects. It was found that in mild and in some cases of moderate hypertension a single daily dose of CP or CP + D is apt to normalize blood pressure for 24 hrs. In patients with moderate and severe hypertension blood pressure is satisfactorily controlled by b.i.d. administration of CP or CP + D. The hypotensive action of the two preparations did not show consistent differences while tolerance was slightly better for CP + D.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/2635103
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact