Synthesis and Characterization of Highly Water-Soluble Dendrofulleropyrrolidine Bisadducts with DNA Binding Activity

The synthesis, characterization and DNA binding studies of a series of polycationic fullerene adducts are reported. These cationic species, exhibiting reasonably high water solubility and a heterogeneous distribution of positive charges, can efficiently complex plasmid DNA. Electrophoresis studies show different DNA binding efficiencies for different adducts, some of which can be considered excellent candidates for DNA binding therapies.



Titolo: Synthesis and Characterization of Highly Water-Soluble Dendrofulleropyrrolidine Bisadducts with DNA Binding Activity
Autori: 
DA ROS, TATIANA
PRATO, MAURIZIO
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Data di pubblicazione: 2012
Rivista: 
ORGANIC LETTERS  
Abstract: The synthesis, characterization and DNA binding studies of a series of polycationic fullerene adducts are reported. These cationic species, exhibiting reasonably high water solubility and a heterogeneous distribution of positive charges, can efficiently complex plasmid DNA. Electrophoresis studies show different DNA binding efficiencies for different adducts, some of which can be considered excellent candidates for DNA binding therapies.
Handle: http://hdl.handle.net/11368/2635510
Digital Object Identifier (DOI): http://dx.doi.org/10.1021/ol301946r
Appare nelle tipologie:1.1 Articolo in Rivista

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