The synthesis of new benzylidenaminoguanidine compounds is described. Some of these compounds were tested for antihypertensive activity in conscious unrestrained spontaneously hypertensive rats. The compounds examined possess a significant antihypertensive activity, qualitatively different from that of clonidine. For the tested compounds, the absence of the transient rise in blood pressure, which appears immediately after administration of clonidine-like drugs, is noteworthy.



Titolo: Antihypertensive activity of arylidenaminoguanidine derivatives.
Autori: 
MAMOLO, MARIA GRAZIA
VIO, LUCIANO
FISCHETTI, Fabio
CARRETTA, RENZO
GIRALDI, TULLIO
mostra contributor esterni 
Data di pubblicazione: 1986
Rivista: 
IL FARMACO. EDIZIONE SCIENTIFICA  
Abstract: The synthesis of new benzylidenaminoguanidine compounds is described. Some of these compounds were tested for antihypertensive activity in conscious unrestrained spontaneously hypertensive rats. The compounds examined possess a significant antihypertensive activity, qualitatively different from that of clonidine. For the tested compounds, the absence of the transient rise in blood pressure, which appears immediately after administration of clonidine-like drugs, is noteworthy.
Handle: http://hdl.handle.net/11368/2635622
Appare nelle tipologie:1.1 Articolo in Rivista

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