FTIs have a dramatic anti-inflammatory effect in models where the mevalonate pathway is chemically or genetically impaired. In our studies, we considered several compounds, such as Tip, Lon and ManA. The effects of Tip and Lon were confirmed by in vitro studies on a cellular model of MKD and on monocytes isolated from MKD patients. The same findings have also been confirmed using the FT inhibitor ManA, according to the results of the in vivo studies. Our findings and those of Hechinger et al. all demonstrate the anti-inflammatory effects of FTIs and GTIs. Given this, FTIs could be used as a novel therapeutic approach for the currently orphan disease MKD, as well as an anti-cancer drug,
Farnesyl and geranylgeranyl transferase inhibitors: an anti-inflammatory effect. Comment to "Inhibition of protein geranylgeranylation and farnesylation protects against graft-versus-host disease via effects on CD4 effector T cells" Haematologica. 2013;98(1):31-40
MARCUZZI, ANNALISA;CAMPISCIANO, GIUSEPPINA;CROVELLA, SERGIO
2013-01-01
Abstract
FTIs have a dramatic anti-inflammatory effect in models where the mevalonate pathway is chemically or genetically impaired. In our studies, we considered several compounds, such as Tip, Lon and ManA. The effects of Tip and Lon were confirmed by in vitro studies on a cellular model of MKD and on monocytes isolated from MKD patients. The same findings have also been confirmed using the FT inhibitor ManA, according to the results of the in vivo studies. Our findings and those of Hechinger et al. all demonstrate the anti-inflammatory effects of FTIs and GTIs. Given this, FTIs could be used as a novel therapeutic approach for the currently orphan disease MKD, as well as an anti-cancer drug,Pubblicazioni consigliate
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