TREX-1 is a restriction factor against HIV-1. The coding sequence of TREX1 gene was analysed in HIV+ subjects searching for genetic variations possibly associated with the susceptibility to HIV infection. The single nucleotide polymorphism rs3135945 was significantly associated with HIV infection, emphasizing the involvement of TREX-1 in the anti-HIV response.
Polymorphisms in TREX1 and susceptibility to HIV-1 infection / Pontillo, Alessandra; Girardelli, Martina; Catamo, Eulalia; Duarte, Aj; Crovella, Sergio. - In: INTERNATIONAL JOURNAL OF IMMUNOGENETICS. - ISSN 1744-3121. - STAMPA. - (2013), pp. 492-494. [10.1111/iji.12071]
Polymorphisms in TREX1 and susceptibility to HIV-1 infection.
PONTILLO, Alessandra;GIRARDELLI, MARTINA;CATAMO, EULALIA;CROVELLA, SERGIO
2013-01-01
Abstract
TREX-1 is a restriction factor against HIV-1. The coding sequence of TREX1 gene was analysed in HIV+ subjects searching for genetic variations possibly associated with the susceptibility to HIV infection. The single nucleotide polymorphism rs3135945 was significantly associated with HIV infection, emphasizing the involvement of TREX-1 in the anti-HIV response.File in questo prodotto:
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