A 2-oxoglutaric acid (2-OG) probe bearing a methylene group introduced at the C4 position and a vinyl group to replace the carbonyl group at the C2 position elicited characteristic affinity for NtcA, the 2-OG receptor, while maintaining the signaling function of the parent natural metabolite 2-OG. This discovery opens new perspectives in the design, synthesis, and implementation of specific 2-OG analogues as molecular probes for investigating the complex 2-OG signaling pathways.
Structural Requirements of 2-Oxoglutaric Acid Analogues To Mimic Its Signaling Function / Liu, X; Wang, Y; Laurini, Erik; Posocco, Paola; Chen, H; Ziarelli, F; Janicki, A; Qu, F; Fermeglia, Maurizio; Pricl, Sabrina; Zhang, Cc; Peng, L.. - In: ORGANIC LETTERS. - ISSN 1523-7060. - STAMPA. - 15:18(2013), pp. 4662-4665. [10.1021/ol401914z]
Structural Requirements of 2-Oxoglutaric Acid Analogues To Mimic Its Signaling Function
LAURINI, ERIK;POSOCCO, PAOLA;FERMEGLIA, MAURIZIO;PRICL, SABRINA;
2013-01-01
Abstract
A 2-oxoglutaric acid (2-OG) probe bearing a methylene group introduced at the C4 position and a vinyl group to replace the carbonyl group at the C2 position elicited characteristic affinity for NtcA, the 2-OG receptor, while maintaining the signaling function of the parent natural metabolite 2-OG. This discovery opens new perspectives in the design, synthesis, and implementation of specific 2-OG analogues as molecular probes for investigating the complex 2-OG signaling pathways.Pubblicazioni consigliate
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