We report a competition assay using our recently reported dye Mallard Blue, which allows us to identify synthetic heparin binders in competitive media, including human serum - using this we gain insight into the ability of PAMAM dendrimers to bind heparin, with the interesting result that low-generation G2-PAMAM is the preferred heparin binder.
Titolo: | A simple new competition assay for heparin binding in serum applied to multivalent PAMAM dendrimers |
Autori: | |
Data di pubblicazione: | 2013 |
Rivista: | |
Abstract: | We report a competition assay using our recently reported dye Mallard Blue, which allows us to identify synthetic heparin binders in competitive media, including human serum - using this we gain insight into the ability of PAMAM dendrimers to bind heparin, with the interesting result that low-generation G2-PAMAM is the preferred heparin binder. |
Handle: | http://hdl.handle.net/11368/2706646 |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1039/c3cc41251b |
Appare nelle tipologie: | 1.1 Articolo in Rivista |
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