We report a competition assay using our recently reported dye Mallard Blue, which allows us to identify synthetic heparin binders in competitive media, including human serum - using this we gain insight into the ability of PAMAM dendrimers to bind heparin, with the interesting result that low-generation G2-PAMAM is the preferred heparin binder.
A simple new competition assay for heparin binding in serum applied to multivalent PAMAM dendrimers / Bromfield, Sm; Posocco, Paola; Fermeglia, Maurizio; Pricl, Sabrina; Rodríguez López, J; Smith, D. K.. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - STAMPA. - 49:42(2013), pp. 4830-4832. [10.1039/c3cc41251b]
A simple new competition assay for heparin binding in serum applied to multivalent PAMAM dendrimers
POSOCCO, PAOLA;FERMEGLIA, MAURIZIO;PRICL, SABRINA;
2013-01-01
Abstract
We report a competition assay using our recently reported dye Mallard Blue, which allows us to identify synthetic heparin binders in competitive media, including human serum - using this we gain insight into the ability of PAMAM dendrimers to bind heparin, with the interesting result that low-generation G2-PAMAM is the preferred heparin binder.Pubblicazioni consigliate
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