A simple new competition assay for heparin binding in serum applied to multivalent PAMAM dendrimers

We report a competition assay using our recently reported dye Mallard Blue, which allows us to identify synthetic heparin binders in competitive media, including human serum - using this we gain insight into the ability of PAMAM dendrimers to bind heparin, with the interesting result that low-generation G2-PAMAM is the preferred heparin binder.



Titolo: A simple new competition assay for heparin binding in serum applied to multivalent PAMAM dendrimers
Autori: 
POSOCCO, PAOLA
FERMEGLIA, MAURIZIO
PRICL, SABRINA
mostra contributor esterni 
Data di pubblicazione: 2013
Rivista: 
CHEMICAL COMMUNICATIONS  
Abstract: We report a competition assay using our recently reported dye Mallard Blue, which allows us to identify synthetic heparin binders in competitive media, including human serum - using this we gain insight into the ability of PAMAM dendrimers to bind heparin, with the interesting result that low-generation G2-PAMAM is the preferred heparin binder.
Handle: http://hdl.handle.net/11368/2706646
Digital Object Identifier (DOI): http://dx.doi.org/10.1039/c3cc41251b
Appare nelle tipologie:1.1 Articolo in Rivista

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