We report a competition assay using our recently reported dye Mallard Blue, which allows us to identify synthetic heparin binders in competitive media, including human serum - using this we gain insight into the ability of PAMAM dendrimers to bind heparin, with the interesting result that low-generation G2-PAMAM is the preferred heparin binder.

A simple new competition assay for heparin binding in serum applied to multivalent PAMAM dendrimers

POSOCCO, PAOLA;FERMEGLIA, MAURIZIO;PRICL, SABRINA;
2013

Abstract

We report a competition assay using our recently reported dye Mallard Blue, which allows us to identify synthetic heparin binders in competitive media, including human serum - using this we gain insight into the ability of PAMAM dendrimers to bind heparin, with the interesting result that low-generation G2-PAMAM is the preferred heparin binder.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/2706646
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