A series of O- and N-prenyl secondary metabolites of insect, fungal, and plant origin have been evaluated for their topical anti-inflammatory activity using the Croton oil ear test in mice as a model of acute inflammation. Some of the tested compounds revealed an effect (ID50 = 0.31 u0.56 μmol/cm2) comparable with that of the reference non-steroidal anti-inflammatory drug indomethacin (ID50 = 0.23 umol/cm2).
In vivo anti-inflammatory activity of some naturally occurring O- and N-prenyl secondary metabolites
DELLA LOGGIA, ROBERTO;TUBARO, AURELIA;SOSA, SILVIO
2014-01-01
Abstract
A series of O- and N-prenyl secondary metabolites of insect, fungal, and plant origin have been evaluated for their topical anti-inflammatory activity using the Croton oil ear test in mice as a model of acute inflammation. Some of the tested compounds revealed an effect (ID50 = 0.31 u0.56 μmol/cm2) comparable with that of the reference non-steroidal anti-inflammatory drug indomethacin (ID50 = 0.23 umol/cm2).File in questo prodotto:
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