Bilirubin-induced brain damage continues to be an important risk among newborns worldwide. Considerable progress has been made in charac- terizing the molecular, biochemical, and cellular events related to bilirubin neurotoxicity, and the importance of non-neuronal cells and cell–cell in- teractions is increasingly apparent. The complex multifactorial nature of this injury continues to confound identification of the threshold for neuro- toxic bilirubin levels and accurate prediction of the clinical occurrence of bilirubin encephalopathy.



Titolo: Bilirubin-induced Neurologic Damage - Mechanisms and Management Approaches (Medical Progress Series).
Autori: 
TIRIBELLI, CLAUDIO
mostra contributor esterni 
Data di pubblicazione: 2013
Rivista: 
NEW ENGLAND JOURNAL OF MEDICINE  
Abstract: Bilirubin-induced brain damage continues to be an important risk among newborns worldwide. Considerable progress has been made in charac- terizing the molecular, biochemical, and cellular events related to bilirubin neurotoxicity, and the importance of non-neuronal cells and cell–cell in- teractions is increasingly apparent. The complex multifactorial nature of this injury continues to confound identification of the threshold for neuro- toxic bilirubin levels and accurate prediction of the clinical occurrence of bilirubin encephalopathy.
Handle: http://hdl.handle.net/11368/2750902
Digital Object Identifier (DOI): 10.1056/NEJMra1308124
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