Bilirubin-induced Neurologic Damage - Mechanisms and Management Approaches (Medical Progress Series).

Bilirubin-induced brain damage continues to be an important risk among newborns worldwide. Considerable progress has been made in charac- terizing the molecular, biochemical, and cellular events related to bilirubin neurotoxicity, and the importance of non-neuronal cells and cell–cell in- teractions is increasingly apparent. The complex multifactorial nature of this injury continues to confound identification of the threshold for neuro- toxic bilirubin levels and accurate prediction of the clinical occurrence of bilirubin encephalopathy.