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EnglishBilirubin-induced brain damage continues to be an important risk among newborns worldwide. Considerable progress has been made in charac- terizing the molecular, biochemical, and cellular events related to bilirubin neurotoxicity, and the importance of non-neuronal cells and cell–cell in- teractions is increasingly apparent. The complex multifactorial nature of this injury continues to confound identification of the threshold for neuro- toxic bilirubin levels and accurate prediction of the clinical occurrence of bilirubin encephalopathy.
| Titolo: | Bilirubin-induced Neurologic Damage - Mechanisms and Management Approaches (Medical Progress Series). |
| Autori: | |
| Data di pubblicazione: | 2013 |
| Rivista: | |
| Abstract: | Bilirubin-induced brain damage continues to be an important risk among newborns worldwide. Considerable progress has been made in charac- terizing the molecular, biochemical, and cellular events related to bilirubin neurotoxicity, and the importance of non-neuronal cells and cell–cell in- teractions is increasingly apparent. The complex multifactorial nature of this injury continues to confound identification of the threshold for neuro- toxic bilirubin levels and accurate prediction of the clinical occurrence of bilirubin encephalopathy. |
| Handle: | http://hdl.handle.net/11368/2750902 |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1056/NEJMra1308124 |
| Appare nelle tipologie: | 1.1 Articolo in Rivista |
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