Organically modified silicates represent an excellent example of organic-inorganic hybrids in materials science. The routes to achieve incorporation of organic functionalities include grafting and co-condensation (one-pot synthesis). Compared with the grafting method, the advantage of one-pot synthesis manifests as the tunability of both mechanical and biological properties. Herein, we report a silsesquioxane-silica hybrid (SqSH) with dual functional groups (alkylammonium and methacrylate chains) synthesized by the hydrolytic co-condensation of one tetraethoxysilane and two alkoxysilanes. Successful co-condensation is validated by attenuated total reflection-Fourier transform infrared (ATR-FTIR), 29Si nuclear magnetic resonance ( 29Si NMR), and thermogravimetric analysis (TGA). 3-(Trimethoxysilyl) propyldimethyloctadecyl ammonium chloride (SiQAC), one of the three precursors, simultaneously serves as a structure-directing agent in the modified Stöber reaction, resulting in SqSH particles with structural hierarchy of both ordered lamellar structure and spherical morphology, as revealed by X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The SqSH particles bear tunable mechanical properties and, when incorporated into bis-GMA/TEGDMA resin, antimicrobial activities against Streptococcus mutans, Actinomyces naeslundii, and Candida albicans.

Synthesis of antimicrobial silsesquioxane-silica hybrids by hydrolytic co-condensation of alkoxysilanes

FRASSETTO, ANDREA;
2014

Abstract

Organically modified silicates represent an excellent example of organic-inorganic hybrids in materials science. The routes to achieve incorporation of organic functionalities include grafting and co-condensation (one-pot synthesis). Compared with the grafting method, the advantage of one-pot synthesis manifests as the tunability of both mechanical and biological properties. Herein, we report a silsesquioxane-silica hybrid (SqSH) with dual functional groups (alkylammonium and methacrylate chains) synthesized by the hydrolytic co-condensation of one tetraethoxysilane and two alkoxysilanes. Successful co-condensation is validated by attenuated total reflection-Fourier transform infrared (ATR-FTIR), 29Si nuclear magnetic resonance ( 29Si NMR), and thermogravimetric analysis (TGA). 3-(Trimethoxysilyl) propyldimethyloctadecyl ammonium chloride (SiQAC), one of the three precursors, simultaneously serves as a structure-directing agent in the modified Stöber reaction, resulting in SqSH particles with structural hierarchy of both ordered lamellar structure and spherical morphology, as revealed by X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The SqSH particles bear tunable mechanical properties and, when incorporated into bis-GMA/TEGDMA resin, antimicrobial activities against Streptococcus mutans, Actinomyces naeslundii, and Candida albicans.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11368/2758964
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