The present manuscript deals with the setup and evaluation of two analytical methods, namely Circular Dichroism (CD) and 23Na longitudinal relaxation, to determine the composition of binary mixtures of the sodium salts of alginate and hyaluronan in solution. The quantitative results obtained were confirmed by 1H NMR, and the developed methods were applied to the determination of the composition and polymer release of mixed hydrogels. Although focused on the specific case of binary mixtures of alginate and hyaluronan, the approach drawn in the present manuscript can find applications in different binary systems composed of natural or synthetic non-interacting polymers.
Determination of the Composition for Binary Mixtures of Polyanions: The Case of Mixed Solutions of Alginate and Hyaluronan
BORGOGNA, MASSIMILIANO ANTONIO;TRAVAN, Andrea;MARSICH, ELEONORA;PAOLETTI, SERGIO;DONATI, IVAN
2014-01-01
Abstract
The present manuscript deals with the setup and evaluation of two analytical methods, namely Circular Dichroism (CD) and 23Na longitudinal relaxation, to determine the composition of binary mixtures of the sodium salts of alginate and hyaluronan in solution. The quantitative results obtained were confirmed by 1H NMR, and the developed methods were applied to the determination of the composition and polymer release of mixed hydrogels. Although focused on the specific case of binary mixtures of alginate and hyaluronan, the approach drawn in the present manuscript can find applications in different binary systems composed of natural or synthetic non-interacting polymers.Pubblicazioni consigliate
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