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EnglishThe use of microbubbles as a contrast agent for x-ray phase contrast imaging could both transform x-ray imaging into a “functional” modality and enable much needed monitoring of targeted drug delivery. To realize these benefits, it is essential to be able to quantify bubble concentration in a given tissue volume. We developed and validated a model that enables this to be achieved not only for phase-retrieved images obtained by processing multiple frames but also on “single-shot” images, a likely necessity in in-vivo implementations. Our experimental validation was based on analyzer-based imaging, but extension to other phase-based modalities is straightforward.
| Titolo: | Quantification of microbubble concentration through x-ray phase contrast imaging |
| Autori: | |
| Data di pubblicazione: | 2013 |
| Rivista: | |
| Abstract: | The use of microbubbles as a contrast agent for x-ray phase contrast imaging could both transform x-ray imaging into a “functional” modality and enable much needed monitoring of targeted drug delivery. To realize these benefits, it is essential to be able to quantify bubble concentration in a given tissue volume. We developed and validated a model that enables this to be achieved not only for phase-retrieved images obtained by processing multiple frames but also on “single-shot” images, a likely necessity in in-vivo implementations. Our experimental validation was based on analyzer-based imaging, but extension to other phase-based modalities is straightforward. |
| Handle: | http://hdl.handle.net/11368/2763900 |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1063/1.4821277 |
| Appare nelle tipologie: | 1.1 Articolo in Rivista |
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