(10)B molecular compounds suitable for Boron Neutron Capture Therapy (BNCT) are tagged with a Gd(III) paramagnetic ion. The newly synthesized molecule, Gd-BPA, is investigated as contrast agent in Magnetic Resonance Imaging (MRI) with the final aim of mapping the boron distribution in tissues. Preliminary Nuclear Magnetic Resonance (NMR) measurements, which include (1)H and (10)B relaxometry in animal tissues, proton relaxivity of the paramagnetic Gd-BPA molecule in water and its absorption in tumoral living cells, are reported.



Titolo: 1H and 10B NMR and MRI investigation of boron- and gadolinium–boron compounds in boron neutron capture therapy
Autori: 
STELLA, SABRINA
mostra contributor esterni 
Data di pubblicazione: 2011
Rivista: 
APPLIED RADIATION AND ISOTOPES  
Abstract: (10)B molecular compounds suitable for Boron Neutron Capture Therapy (BNCT) are tagged with a Gd(III) paramagnetic ion. The newly synthesized molecule, Gd-BPA, is investigated as contrast agent in Magnetic Resonance Imaging (MRI) with the final aim of mapping the boron distribution in tissues. Preliminary Nuclear Magnetic Resonance (NMR) measurements, which include (1)H and (10)B relaxometry in animal tissues, proton relaxivity of the paramagnetic Gd-BPA molecule in water and its absorption in tumoral living cells, are reported.
Handle: http://hdl.handle.net/11368/2769401
Digital Object Identifier (DOI): http://dx.doi.org/10.1016/j.apradiso.2011.02.021
Appare nelle tipologie:1.1 Articolo in Rivista

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