In recent years, understanding cell mechanics has gained increasing importance, with significant implications for human health. Currently, different technologies have been developed to perform the mechanical stimulation of living cells. However, they often show some limitations. Here we present the development and characterization of a novel microelectromechanical system(MEMS), designed to perform a multidirectional mechanical stimulation of single living cells: in this way, in vitro cell behavior is closely simulated. The proposed device employs a newcompliant spring linkage tomove a twelve-slice sectioned plate that works as a seating platform for the cell under study. The whole platform is moved bymeans of four series of bimorph thermal actuators, which allow displacements in 12 directions in the x–y plane. Results showtheworkability of the device under certain conditions, with important implications for a better understanding of cell mechanics and related disease.

A novel MEMS device for the multidirectional mechanical stimulation of single cells: Preliminary results

MAGGIOLINO, STEFANO;SCUOR, NICOLA;GALLINA, PAOLO;SBAIZERO, ORFEO
2014

Abstract

In recent years, understanding cell mechanics has gained increasing importance, with significant implications for human health. Currently, different technologies have been developed to perform the mechanical stimulation of living cells. However, they often show some limitations. Here we present the development and characterization of a novel microelectromechanical system(MEMS), designed to perform a multidirectional mechanical stimulation of single living cells: in this way, in vitro cell behavior is closely simulated. The proposed device employs a newcompliant spring linkage tomove a twelve-slice sectioned plate that works as a seating platform for the cell under study. The whole platform is moved bymeans of four series of bimorph thermal actuators, which allow displacements in 12 directions in the x–y plane. Results showtheworkability of the device under certain conditions, with important implications for a better understanding of cell mechanics and related disease.
File in questo prodotto:
File Dimensione Formato  
scuor_1-s2.0-S0094114X14000871-main.pdf

non disponibili

Tipologia: Documento in Versione Editoriale
Licenza: Digital Rights Management non definito
Dimensione 1.35 MB
Formato Adobe PDF
1.35 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11368/2779524
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 8
  • ???jsp.display-item.citation.isi??? 8
social impact