We report here that the established anticancer ruthenium( III ) complex NAMI-A induces potent and selective cytotoxic e ff ects in a few leukaemia cell lines. These results sound very surprising after 20 years of intense studies on NAMI-A, commonly considered as a “ non-cytotoxic ” antimetastatic agent. In addition, evidence is given for selective inhibition of KCa 3.1 channels. The implications of these fi ndings are discussed.

NAMI-A is highly cytotoxic toward leukaemia cell lines: evidence of inhibition of KCa 3.1 channels

ALESSIO, ENZO;
2014-01-01

Abstract

We report here that the established anticancer ruthenium( III ) complex NAMI-A induces potent and selective cytotoxic e ff ects in a few leukaemia cell lines. These results sound very surprising after 20 years of intense studies on NAMI-A, commonly considered as a “ non-cytotoxic ” antimetastatic agent. In addition, evidence is given for selective inhibition of KCa 3.1 channels. The implications of these fi ndings are discussed.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/2798728
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 36
  • ???jsp.display-item.citation.isi??? 35
social impact