We report here that the established anticancer ruthenium( III ) complex NAMI-A induces potent and selective cytotoxic e ff ects in a few leukaemia cell lines. These results sound very surprising after 20 years of intense studies on NAMI-A, commonly considered as a “ non-cytotoxic ” antimetastatic agent. In addition, evidence is given for selective inhibition of KCa 3.1 channels. The implications of these fi ndings are discussed.
NAMI-A is highly cytotoxic toward leukaemia cell lines: evidence of inhibition of KCa 3.1 channels
ALESSIO, ENZO;
2014-01-01
Abstract
We report here that the established anticancer ruthenium( III ) complex NAMI-A induces potent and selective cytotoxic e ff ects in a few leukaemia cell lines. These results sound very surprising after 20 years of intense studies on NAMI-A, commonly considered as a “ non-cytotoxic ” antimetastatic agent. In addition, evidence is given for selective inhibition of KCa 3.1 channels. The implications of these fi ndings are discussed.File in questo prodotto:
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