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EnglishThe peculiar higher solubility of drug nanocrystals compared to macrocrystals appeals to the pharmaceutical field. Indeed, until now, about 70 % of the potential drug candidates are discarded due to low bioavailability related with poor solubility in water. Since a modern and efficient design strategy for nanocrystal-based delivery systems requires the knowledge of the theoretical relation between nanocrystal size and solubility, the aim of this paper is to build up a physically-oriented thermodynamic model relating to nanocrystal dimensions with their melting temperature, enthalpy, solubility and dissolution rate. In particular, the developed model will be applied to vinpocetine, a poorly soluble drug used in the treatment of various types of cerebrovascular circulatory disorders
| Titolo: | Drug Nanocrystals: theoretical background of solubility increase and dissolution rate enhancement | |
| Autori: | ||
| Data di pubblicazione: | 2014 | |
| Stato di pubblicazione: | Pubblicato | |
| Rivista: | ||
| Abstract: | The peculiar higher solubility of drug nanocrystals compared to macrocrystals appeals to the pharmaceutical field. Indeed, until now, about 70 % of the potential drug candidates are discarded due to low bioavailability related with poor solubility in water. Since a modern and efficient design strategy for nanocrystal-based delivery systems requires the knowledge of the theoretical relation between nanocrystal size and solubility, the aim of this paper is to build up a physically-oriented thermodynamic model relating to nanocrystal dimensions with their melting temperature, enthalpy, solubility and dissolution rate. In particular, the developed model will be applied to vinpocetine, a poorly soluble drug used in the treatment of various types of cerebrovascular circulatory disorders | |
| Handle: | http://hdl.handle.net/11368/2808930 | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.15255/CABEQ.2013.1835 | |
| Appare nelle tipologie: | 1.1 Articolo in Rivista |