Drug Nanocrystals: theoretical background of solubility increase and dissolution rate enhancement

The peculiar higher solubility of drug nanocrystals compared to macrocrystals appeals to the pharmaceutical field. Indeed, until now, about 70 % of the potential drug candidates are discarded due to low bioavailability related with poor solubility in water. Since a modern and efficient design strategy for nanocrystal-based delivery systems requires the knowledge of the theoretical relation between nanocrystal size and solubility, the aim of this paper is to build up a physically-oriented thermodynamic model relating to nanocrystal dimensions with their melting temperature, enthalpy, solubility and dissolution rate. In particular, the developed model will be applied to vinpocetine, a poorly soluble drug used in the treatment of various types of cerebrovascular circulatory disorders



Titolo: Drug Nanocrystals: theoretical background of solubility increase and dissolution rate enhancement
Autori: 
HASA, DRITAN
PERISSUTTI, Beatrice
VOINOVICH, DARIO
ABRAMI, MICHELA
FARRA, ROSSELLA
FIORENTINO, SIMONA MARIA
GRASSI, GABRIELE
GRASSI, Mario
Data di pubblicazione: 2014
Stato di pubblicazione: Pubblicato
Rivista: 
CHEMICAL AND BIOCHEMICAL ENGINEERING QUARTERLY  
Abstract: The peculiar higher solubility of drug nanocrystals compared to macrocrystals appeals to the pharmaceutical field. Indeed, until now, about 70 % of the potential drug candidates are discarded due to low bioavailability related with poor solubility in water. Since a modern and efficient design strategy for nanocrystal-based delivery systems requires the knowledge of the theoretical relation between nanocrystal size and solubility, the aim of this paper is to build up a physically-oriented thermodynamic model relating to nanocrystal dimensions with their melting temperature, enthalpy, solubility and dissolution rate. In particular, the developed model will be applied to vinpocetine, a poorly soluble drug used in the treatment of various types of cerebrovascular circulatory disorders
Handle: http://hdl.handle.net/11368/2808930
Digital Object Identifier (DOI): http://dx.doi.org/10.15255/CABEQ.2013.1835
Appare nelle tipologie:1.1 Articolo in Rivista

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