Theidentificationofdifferentpoolsofcardiacprogenitorcellsresidentintheadultmammalianheartopenedanewerainheartregenerationasameanstorestorethelossoffunctionalcardiactissueandovercomethelimitedavailabilityofdonororgans.Indeed,residentstemcellsarebelievedtoparticipatetotissuehomeostasisandrenewalinhealthyanddamagedmyocardiumalthoughtheiractualcontributiontotheseprocessesremainunclear.ThepooroutcomeintermsofcardiacregenerationfollowingtissuedamagepointoutattheneedforadeeperunderstandingofthemolecularmechanismscontrollingCPCbehaviorandfatedeterminationbeforenewtherapeuticstrategiescanbedeveloped.Theregulationofcardiacresidentstemcellfateandfunctionislikelytoresultfromtheinterplaybetweenpleiotropicsignalingpathwaysaswellastissue-andcell-specificregulators.Suchamodularinteraction—whichhasalreadybeendescribedinthenucleusofanumberofdifferentcellswheretranscriptionalcomplexesformtoactivatespecificgeneprograms—wouldaccountfortheuniqueresponsesofcardiacprogenitorstogeneralandtissue-specificstimuli.Thestudyofthemoleculardeterminantsinvolvedincardiacstem/progenitorcellregulatorymechanismsmayshedlightontheprocessesofcardiachomeostasisinhealthanddiseaseandthusprovidecluesontheactualfeasibilityofcardiaccelltherapythroughtissue-specificprogenitors.



Titolo: Targeting pleiotropic signaling pathways to control adult cardiac stem cell fate and function
Autori: 
GRASSI, GABRIELE
mostra contributor esterni 
Data di pubblicazione: 2014
Rivista: 
FRONTIERS IN PHYSIOLOGY  
Abstract: Theidentificationofdifferentpoolsofcardiacprogenitorcellsresidentintheadultmammalianheartopenedanewerainheartregenerationasameanstorestorethelossoffunctionalcardiactissueandovercomethelimitedavailabilityofdonororgans.Indeed,residentstemcellsarebelievedtoparticipatetotissuehomeostasisandrenewalinhealthyanddamagedmyocardiumalthoughtheiractualcontributiontotheseprocessesremainunclear.ThepooroutcomeintermsofcardiacregenerationfollowingtissuedamagepointoutattheneedforadeeperunderstandingofthemolecularmechanismscontrollingCPCbehaviorandfatedeterminationbeforenewtherapeuticstrategiescanbedeveloped.Theregulationofcardiacresidentstemcellfateandfunctionislikelytoresultfromtheinterplaybetweenpleiotropicsignalingpathwaysaswellastissue-andcell-specificregulators.Suchamodularinteraction—whichhasalreadybeendescribedinthenucleusofanumberofdifferentcellswheretranscriptionalcomplexesformtoactivatespecificgeneprograms—wouldaccountfortheuniqueresponsesofcardiacprogenitorstogeneralandtissue-specificstimuli.Thestudyofthemoleculardeterminantsinvolvedincardiacstem/progenitorcellregulatorymechanismsmayshedlightontheprocessesofcardiachomeostasisinhealthanddiseaseandthusprovidecluesontheactualfeasibilityofcardiaccelltherapythroughtissue-specificprogenitors.
Handle: http://hdl.handle.net/11368/2814939
Digital Object Identifier (DOI): http://dx.doi.org/10.3389/fphys.2014.00219
Appare nelle tipologie:1.1 Articolo in Rivista

File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
 
 
 
©2014 University of Trieste dove siamo Privacy
Piazzale Europa,1 34127 Trieste, Italia - Tel. +39 040.558.7111 - P.IVA 00211830328 - C.F. 80013890324 - P.E.C.: ateneo@pec.units.it
 Copyright © 2020