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EnglishTheidentificationofdifferentpoolsofcardiacprogenitorcellsresidentintheadultmammalianheartopenedanewerainheartregenerationasameanstorestorethelossoffunctionalcardiactissueandovercomethelimitedavailabilityofdonororgans.Indeed,residentstemcellsarebelievedtoparticipatetotissuehomeostasisandrenewalinhealthyanddamagedmyocardiumalthoughtheiractualcontributiontotheseprocessesremainunclear.ThepooroutcomeintermsofcardiacregenerationfollowingtissuedamagepointoutattheneedforadeeperunderstandingofthemolecularmechanismscontrollingCPCbehaviorandfatedeterminationbeforenewtherapeuticstrategiescanbedeveloped.Theregulationofcardiacresidentstemcellfateandfunctionislikelytoresultfromtheinterplaybetweenpleiotropicsignalingpathwaysaswellastissue-andcell-specificregulators.Suchamodularinteraction—whichhasalreadybeendescribedinthenucleusofanumberofdifferentcellswheretranscriptionalcomplexesformtoactivatespecificgeneprograms—wouldaccountfortheuniqueresponsesofcardiacprogenitorstogeneralandtissue-specificstimuli.Thestudyofthemoleculardeterminantsinvolvedincardiacstem/progenitorcellregulatorymechanismsmayshedlightontheprocessesofcardiachomeostasisinhealthanddiseaseandthusprovidecluesontheactualfeasibilityofcardiaccelltherapythroughtissue-specificprogenitors.
| Titolo: | Targeting pleiotropic signaling pathways to control adult cardiac stem cell fate and function |
| Autori: | |
| Data di pubblicazione: | 2014 |
| Rivista: | |
| Abstract: | Theidentificationofdifferentpoolsofcardiacprogenitorcellsresidentintheadultmammalianheartopenedanewerainheartregenerationasameanstorestorethelossoffunctionalcardiactissueandovercomethelimitedavailabilityofdonororgans.Indeed,residentstemcellsarebelievedtoparticipatetotissuehomeostasisandrenewalinhealthyanddamagedmyocardiumalthoughtheiractualcontributiontotheseprocessesremainunclear.ThepooroutcomeintermsofcardiacregenerationfollowingtissuedamagepointoutattheneedforadeeperunderstandingofthemolecularmechanismscontrollingCPCbehaviorandfatedeterminationbeforenewtherapeuticstrategiescanbedeveloped.Theregulationofcardiacresidentstemcellfateandfunctionislikelytoresultfromtheinterplaybetweenpleiotropicsignalingpathwaysaswellastissue-andcell-specificregulators.Suchamodularinteraction—whichhasalreadybeendescribedinthenucleusofanumberofdifferentcellswheretranscriptionalcomplexesformtoactivatespecificgeneprograms—wouldaccountfortheuniqueresponsesofcardiacprogenitorstogeneralandtissue-specificstimuli.Thestudyofthemoleculardeterminantsinvolvedincardiacstem/progenitorcellregulatorymechanismsmayshedlightontheprocessesofcardiachomeostasisinhealthanddiseaseandthusprovidecluesontheactualfeasibilityofcardiaccelltherapythroughtissue-specificprogenitors. |
| Handle: | http://hdl.handle.net/11368/2814939 |
| Digital Object Identifier (DOI): | 10.3389/fphys.2014.00219 |
| Appare nelle tipologie: | 1.1 Articolo in Rivista |