Theidentificationofdifferentpoolsofcardiacprogenitorcellsresidentintheadultmammalianheartopenedanewerainheartregenerationasameanstorestorethelossoffunctionalcardiactissueandovercomethelimitedavailabilityofdonororgans.Indeed,residentstemcellsarebelievedtoparticipatetotissuehomeostasisandrenewalinhealthyanddamagedmyocardiumalthoughtheiractualcontributiontotheseprocessesremainunclear.ThepooroutcomeintermsofcardiacregenerationfollowingtissuedamagepointoutattheneedforadeeperunderstandingofthemolecularmechanismscontrollingCPCbehaviorandfatedeterminationbeforenewtherapeuticstrategiescanbedeveloped.Theregulationofcardiacresidentstemcellfateandfunctionislikelytoresultfromtheinterplaybetweenpleiotropicsignalingpathwaysaswellastissue-andcell-specificregulators.Suchamodularinteraction—whichhasalreadybeendescribedinthenucleusofanumberofdifferentcellswheretranscriptionalcomplexesformtoactivatespecificgeneprograms—wouldaccountfortheuniqueresponsesofcardiacprogenitorstogeneralandtissue-specificstimuli.Thestudyofthemoleculardeterminantsinvolvedincardiacstem/progenitorcellregulatorymechanismsmayshedlightontheprocessesofcardiachomeostasisinhealthanddiseaseandthusprovidecluesontheactualfeasibilityofcardiaccelltherapythroughtissue-specificprogenitors.
Titolo: | Targeting pleiotropic signaling pathways to control adult cardiac stem cell fate and function |
Autori: | |
Data di pubblicazione: | 2014 |
Rivista: | |
Abstract: | Theidentificationofdifferentpoolsofcardiacprogenitorcellsresidentintheadultmammalianheartopenedanewerainheartregenerationasameanstorestorethelossoffunctionalcardiactissueandovercomethelimitedavailabilityofdonororgans.Indeed,residentstemcellsarebelievedtoparticipatetotissuehomeostasisandrenewalinhealthyanddamagedmyocardiumalthoughtheiractualcontributiontotheseprocessesremainunclear.ThepooroutcomeintermsofcardiacregenerationfollowingtissuedamagepointoutattheneedforadeeperunderstandingofthemolecularmechanismscontrollingCPCbehaviorandfatedeterminationbeforenewtherapeuticstrategiescanbedeveloped.Theregulationofcardiacresidentstemcellfateandfunctionislikelytoresultfromtheinterplaybetweenpleiotropicsignalingpathwaysaswellastissue-andcell-specificregulators.Suchamodularinteraction—whichhasalreadybeendescribedinthenucleusofanumberofdifferentcellswheretranscriptionalcomplexesformtoactivatespecificgeneprograms—wouldaccountfortheuniqueresponsesofcardiacprogenitorstogeneralandtissue-specificstimuli.Thestudyofthemoleculardeterminantsinvolvedincardiacstem/progenitorcellregulatorymechanismsmayshedlightontheprocessesofcardiachomeostasisinhealthanddiseaseandthusprovidecluesontheactualfeasibilityofcardiaccelltherapythroughtissue-specificprogenitors. |
Handle: | http://hdl.handle.net/11368/2814939 |
Digital Object Identifier (DOI): | http://dx.doi.org/10.3389/fphys.2014.00219 |
Appare nelle tipologie: | 1.1 Articolo in Rivista |