Theidentificationofdifferentpoolsofcardiacprogenitorcellsresidentintheadultmammalianheartopenedanewerainheartregenerationasameanstorestorethelossoffunctionalcardiactissueandovercomethelimitedavailabilityofdonororgans.Indeed,residentstemcellsarebelievedtoparticipatetotissuehomeostasisandrenewalinhealthyanddamagedmyocardiumalthoughtheiractualcontributiontotheseprocessesremainunclear.ThepooroutcomeintermsofcardiacregenerationfollowingtissuedamagepointoutattheneedforadeeperunderstandingofthemolecularmechanismscontrollingCPCbehaviorandfatedeterminationbeforenewtherapeuticstrategiescanbedeveloped.Theregulationofcardiacresidentstemcellfateandfunctionislikelytoresultfromtheinterplaybetweenpleiotropicsignalingpathwaysaswellastissue-andcell-specificregulators.Suchamodularinteraction—whichhasalreadybeendescribedinthenucleusofanumberofdifferentcellswheretranscriptionalcomplexesformtoactivatespecificgeneprograms—wouldaccountfortheuniqueresponsesofcardiacprogenitorstogeneralandtissue-specificstimuli.Thestudyofthemoleculardeterminantsinvolvedincardiacstem/progenitorcellregulatorymechanismsmayshedlightontheprocessesofcardiachomeostasisinhealthanddiseaseandthusprovidecluesontheactualfeasibilityofcardiaccelltherapythroughtissue-specificprogenitors.
Targeting pleiotropic signaling pathways to control adult cardiac stem cell fate and function
GRASSI, GABRIELE;Forte, Giancarlo
2014-01-01
Abstract
Theidentificationofdifferentpoolsofcardiacprogenitorcellsresidentintheadultmammalianheartopenedanewerainheartregenerationasameanstorestorethelossoffunctionalcardiactissueandovercomethelimitedavailabilityofdonororgans.Indeed,residentstemcellsarebelievedtoparticipatetotissuehomeostasisandrenewalinhealthyanddamagedmyocardiumalthoughtheiractualcontributiontotheseprocessesremainunclear.ThepooroutcomeintermsofcardiacregenerationfollowingtissuedamagepointoutattheneedforadeeperunderstandingofthemolecularmechanismscontrollingCPCbehaviorandfatedeterminationbeforenewtherapeuticstrategiescanbedeveloped.Theregulationofcardiacresidentstemcellfateandfunctionislikelytoresultfromtheinterplaybetweenpleiotropicsignalingpathwaysaswellastissue-andcell-specificregulators.Suchamodularinteraction—whichhasalreadybeendescribedinthenucleusofanumberofdifferentcellswheretranscriptionalcomplexesformtoactivatespecificgeneprograms—wouldaccountfortheuniqueresponsesofcardiacprogenitorstogeneralandtissue-specificstimuli.Thestudyofthemoleculardeterminantsinvolvedincardiacstem/progenitorcellregulatorymechanismsmayshedlightontheprocessesofcardiachomeostasisinhealthanddiseaseandthusprovidecluesontheactualfeasibilityofcardiaccelltherapythroughtissue-specificprogenitors.Pubblicazioni consigliate
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