Reaction of trans-[Pt(CH3NH2)2(1-MeC-N3)2]X2 (1-MeC =1-methylcytosine; X = NO3– or ClO4–) with Na[AuCl4] in strongly alkaline aqueous solution yields an asymmetrical double helicate containing two central PtII as well as AuIII and AuI atoms, four 1-methylcytosinato bridges (1-MeC–-N3,N4), two terminal methylamine and two bridging methylamido ligands, [Au2Pt2(CH3NH2)2(CH3NH)2(1-MeC–)4]Cl2·2H2O (2). The four 1-MeC– ligands, which are pairwise oriented in head-head fashion, are deprotonated at their N4 positions and cross-linked by the gold ions.
A Unique Helicate Comprised of Four Cytosine Nucleobases and Four Metal Entities (PtII, PtII, AuIII, AuI). Implications for the Interactions of Linearly Coordinated Metal Ions with Nucleotide Duplexes
ZANGRANDO, ENNIO;RANDACCIO, LUCIO;
2013-01-01
Abstract
Reaction of trans-[Pt(CH3NH2)2(1-MeC-N3)2]X2 (1-MeC =1-methylcytosine; X = NO3– or ClO4–) with Na[AuCl4] in strongly alkaline aqueous solution yields an asymmetrical double helicate containing two central PtII as well as AuIII and AuI atoms, four 1-methylcytosinato bridges (1-MeC–-N3,N4), two terminal methylamine and two bridging methylamido ligands, [Au2Pt2(CH3NH2)2(CH3NH)2(1-MeC–)4]Cl2·2H2O (2). The four 1-MeC– ligands, which are pairwise oriented in head-head fashion, are deprotonated at their N4 positions and cross-linked by the gold ions.File in questo prodotto:
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