A series of monodentate and bidentate chiral phosphorus based ligands including diphosphites and diphosphonites derived from carbohydrates were tested in the asymmetric Suzuki coupling of aryl halides with 2-substituted 1-naphthylboronic acids. Good activities and selectivities were achieved, although modest ee's were obtained (up to 37%). The X-ray structure of PtCl2(12) bearing the C2-symmetry diphosphite ligand 12 derived from carbohydrate, is also reported.
Pd-catalysed asymmetric Suzuki–Miyaura reactions using chiral mono- and bidentate phosphorus ligands / Castillo, Angelica Balanta; Perandones, Bernabé F.; Zangrando, Ennio; Gladiali, Serafino; Godard, Cyril; Claver, Carmen. - In: JOURNAL OF ORGANOMETALLIC CHEMISTRY. - ISSN 0022-328X. - STAMPA. - 743:(2013), pp. 31-36. [10.1016/j.jorganchem.2013.06.022]
Pd-catalysed asymmetric Suzuki–Miyaura reactions using chiral mono- and bidentate phosphorus ligands
ZANGRANDO, ENNIO;
2013-01-01
Abstract
A series of monodentate and bidentate chiral phosphorus based ligands including diphosphites and diphosphonites derived from carbohydrates were tested in the asymmetric Suzuki coupling of aryl halides with 2-substituted 1-naphthylboronic acids. Good activities and selectivities were achieved, although modest ee's were obtained (up to 37%). The X-ray structure of PtCl2(12) bearing the C2-symmetry diphosphite ligand 12 derived from carbohydrate, is also reported.Pubblicazioni consigliate
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