Defects in the cell-cycle surveillance mechanism, called the spindle checkpoint, might contribute to the chromosomal instability observed in human cancers, including oral squamous cell carcinoma. MAD2 and BUBR1 are key components of the spindle checkpoint, whose role in oral carcinogenesis and clinical relevance still need to be elucidated.

MAD2 Expression in Oral Squamous Cell Carcinoma and its Relationship to Tumor Grade and Proliferation

RIZZARDI, CLARA;TORELLI, LUCIO;SCHNEIDER, MANUELA;GIUDICI, FABIOLA;BIASOTTO, MATTEO;DI LENARDA, Roberto;MELATO, MAURO
2014

Abstract

Defects in the cell-cycle surveillance mechanism, called the spindle checkpoint, might contribute to the chromosomal instability observed in human cancers, including oral squamous cell carcinoma. MAD2 and BUBR1 are key components of the spindle checkpoint, whose role in oral carcinogenesis and clinical relevance still need to be elucidated.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11368/2830313
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