Direct delivery of bioactive substances to the sites of injury represents a key issue for therapies based on regenerative medicine and tissue repair [1]. Protein derived hydrogels represent an interesting system for this purpose because they possess several features that make them suitable to this purpose. A method for preparation of hydrogel matrices based on Human Elastin-like Polypeptide (HELP) has been set up [2]. HELPs are a family of elastin-like recombinant biopolymers modeled after the most regularly repeated domain in human tropoelastin, retaining peculiar properties as self-assembling and thermoresponsive behavior [3]. In this study we assayed two elastolytic activities from different sources to test their potential to specifically degrade the HELP matrix.



Titolo: HELP-based matrices for stimuli-responsive controlled release of bioactive compounds
Autori: 
CORICH, LUCIA
BORELLI, VIOLETTA
VITA, FRANCESCA
BANDIERA, Antonella
mostra contributor esterni 
Data di pubblicazione: 2013
Rivista: 
EUROPEAN CELLS & MATERIALS  
Abstract: Direct delivery of bioactive substances to the sites of injury represents a key issue for therapies based on regenerative medicine and tissue repair [1]. Protein derived hydrogels represent an interesting system for this purpose because they possess several features that make them suitable to this purpose. A method for preparation of hydrogel matrices based on Human Elastin-like Polypeptide (HELP) has been set up [2]. HELPs are a family of elastin-like recombinant biopolymers modeled after the most regularly repeated domain in human tropoelastin, retaining peculiar properties as self-assembling and thermoresponsive behavior [3]. In this study we assayed two elastolytic activities from different sources to test their potential to specifically degrade the HELP matrix.
Handle: http://hdl.handle.net/11368/2830337
URL: http://www.ecmjournal.org/journal/supplements/vol026supp06/pdf/Vol026Supp06a093.pdf
Appare nelle tipologie:1.1 Articolo in Rivista

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