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EnglishDirect delivery of bioactive substances to the sites of injury represents a key issue for therapies based on regenerative medicine and tissue repair [1]. Protein derived hydrogels represent an interesting system for this purpose because they possess several features that make them suitable to this purpose. A method for preparation of hydrogel matrices based on Human Elastin-like Polypeptide (HELP) has been set up [2]. HELPs are a family of elastin-like recombinant biopolymers modeled after the most regularly repeated domain in human tropoelastin, retaining peculiar properties as self-assembling and thermoresponsive behavior [3]. In this study we assayed two elastolytic activities from different sources to test their potential to specifically degrade the HELP matrix.
| Titolo: | HELP-based matrices for stimuli-responsive controlled release of bioactive compounds |
| Autori: | |
| Data di pubblicazione: | 2013 |
| Rivista: | |
| Abstract: | Direct delivery of bioactive substances to the sites of injury represents a key issue for therapies based on regenerative medicine and tissue repair [1]. Protein derived hydrogels represent an interesting system for this purpose because they possess several features that make them suitable to this purpose. A method for preparation of hydrogel matrices based on Human Elastin-like Polypeptide (HELP) has been set up [2]. HELPs are a family of elastin-like recombinant biopolymers modeled after the most regularly repeated domain in human tropoelastin, retaining peculiar properties as self-assembling and thermoresponsive behavior [3]. In this study we assayed two elastolytic activities from different sources to test their potential to specifically degrade the HELP matrix. |
| Handle: | http://hdl.handle.net/11368/2830337 |
| URL: | http://www.ecmjournal.org/journal/supplements/vol026supp06/pdf/Vol026Supp06a093.pdf |
| Appare nelle tipologie: | 1.1 Articolo in Rivista |
